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약용 식물 추출물의 항산화 활성 검색
Screening for Antioxidant Activity of Plant Medicinal Extracts

정성제   (경희대학교 생명공학원 및 식물대사 연구센터UU0001575  ); 이진희   (경희대학교 생명공학원 및 식물대사 연구센터UU0001575  ); 송효남   (세명대학교 한방식품영양학과UU0000787  ); 성낙술   (농촌진흥청 농업기술원 작물시험장CC0187065  ); 이승은   (농촌진흥청 농업기술원 작물시험장CC0187065  ); 백남인   (경희대학교 생명공학원 및 식물대사 연구센터UU0001575  );
  • 초록

    현재 시판되고 있는 한약재 및 약용식물 118종에 대해서 80% 메탄올 추출물을 제조하였고 , 이들의 항산화 활성을 DPPH 와 superoxide anion radical 소거능 측정 방법을 이용하여 조사하였다. DPPH radical 소거 활성은 괴화 (Sophora japonica: 줄기부)의 메탄올 추출물에서 76.9%의 활성을 보였고 회수(Camptotheca acuminata Dence: 지상부)의 추출물에서는 50.9%의 활성을 보였으며 박하(Mentha arvensis: 지상부), 비파엽 (Eriobotryajaponica: 지상부), 소엽(Perilla frutescens: 줄기부), 애엽(Artemisia asiatica: 줄기부 ), 초과(Amomum. costatum: 지상부) 의 추출물과 산비장이(Serratula koreana: 잎), 살구나무(Prunus ansu: 잎)는 30% 이상의 활성을 보였다. Superoxide anion radical 소거능은 박하(Mentha arvensis), 비파엽(Eriobotrya jαponica), 초과(Amomum costatum), 희수(Camptotheca acuminata Dence)의 지상부에서 80% 이상의 활성을 보였으며 괴화(Sophora jαponica), 소엽(Perilla frutescens), 애엽(Artemisia asiatica), 순비기나무 (Vitex rotundifolia)의 줄기부 , 짚신나물(Agrimonia pilosa)의 잎, 창질경이(Plantago lanceolata) 지상부는 50% 이상의 활성을 나타내었다. 박하(Mentha arvensis) 와 비파엽(Eriobotrya jαponica), 초과(Amomum costatum), 희수(Camptotheca acuminata Dence)의 지상 부는 DPPH뿐만 아니라 superoxide anion radical 소거능에서도 높은 활성을 보였다.


    The antioxidant activities of 80% methanol extracts obtained from 118 medicinal plants were tested through the evaluation of DPPH and superoxide anion radicals scavenging activity. Methanol extracts of Sophora japonica (76.9%) and Camptotheca acuminata Dence (50.9%) were found to have more than 50% DPPH radical scavenging activity while those of Perilla frutescens (37.2%), Amomum costatum (34.9%), Prunus ansu (33.2%), Mentha arvensis (32.3%), Serratula koreana (32.2%), Eriobotrya japonica (30.5%), and Artemisia asiatica (30.5%) showed more than 30% scavenging activity. Even though all of the commercial antioxidants didn't show superoxide anion radical activity, Mentha arvensis (87.7%), Eriobotrya japonica (84.9%), Amomum costatum (82.9%), Camptotheca acuminata Dence (82.1%) showed more than 80% scavenging activity. Mentha arvensis, Eriobotrya japonica, Amomum costatum, Camptotheca acuminata Dence showed strong antioxidative activity in the both DPPH and superoxide anion radical scavenging activities.


  • 주제어

    항산화 활성 .   박하 .   비파엽 .   초과 .   희수.  

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    54. Ling, Jin ; Ha, Ji-Hye ; Choi, Yoon-Yong ; Seo, Yong-Chang ; Kim, Ji-Seon ; Kim, Young-Ock ; Cha, Seon-Woo ; Kim, Jin-Chul ; Lee, Hyeon-Yong 2011. "Enhancement of Cosmeceutical Activities of Berberis koreana Bark by High Pressure and Ultrasonification Extraction Processes" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 19(1): 54~65     
    55. Cho, Eun-Ah ; Cho, Eun-Hye ; Choi, Sun-Ju ; Park, Keun-Hyoung ; Kim, So-Young ; Jeong, Yoon-Joo ; Ku, Chang-Sub ; Ha, Byung-Jhip ; Jang, Dong-Il ; Chae, Hee-Jeong 2011. "Screening of Anti-wrinkle Resource from Herbal Medicinal Extracts and Stability Test of Its Cosmetic Products" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 19(2): 126~135     
    56. Gim, Seon-Bin ; Kim, Soo-Myung ; Kim, Dong-Hee 2011. "Effects of Baedokhwanbalhyobang (BDHBH) on Immune Modulation in Dermatitis Model of NC/Nga Mice" 論文集 : 大田大學校 韓醫學硏究所. 韓醫學編, 19(2): 101~118     
    57. Jeon, Yeon-Hee ; Won, Ji-Hye ; Kwon, Ji-Eun ; Kim, Mee-Ra 2011. "Antioxidant Activity and Cytotoxic Effect of an Ethanol Extract from Seoritae" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 27(3): 1~10     
    58. Lee, Hye-Jin ; Park, Soo-Nam 2011. "Antioxidative Effect and Active Component Analysis of Quercus salicina Blume Extracts" 大韓化粧品學會誌 = Journal of the society of cosmetic scientists of Korea, 37(2): 143~152     
    59. Park, Jong-In ; Jung, Hee-Jeong ; Bae, Yong-Hui ; Kang, Kwon-Kyoo ; Nou, Ill-Sup 2011. "Antimicrobial Activity against Potato Common Scab (Streptomyces scabiei) of Green Manure Crop Extracts" 韓國資源植物學會誌 = Korean journal of plant resources, 24(5): 622~627     
    60. Kim, Hyun Young ; Ko, Jee Yeon ; Song, Seuk Bo ; Kim, Jung In ; Seo, Hye In ; Lee, Jae Saeng ; Kwak, Do Yeon ; Jung, Tae Wook ; Kim, Ki Young ; Oh, In Seok ; Jeong, Heon Sang ; Woo, Koan Sik 2012. "Antioxidant Activities of Solvent Fractions from Methanolic Extract of Cockscome (Celosia cristata L.) Flowers" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 41(11): 1502~1507     
    61. Kim, Hyun Young ; Ko, Jee Yeon ; Song, Seuk Bo ; Kim, Jung In ; Seo, Hye In ; Lee, Jae Saeng ; Kwak, Do Yeon ; Jung, Tae Wook ; Kim, Ki Young ; Oh, In Seok ; Jeong, Heon Sang ; Woo, Koan Sik 2012. "Antioxidant and α-Glucosidase Inhibition Activities of Solvent Fractions from Methanolic Extract of Sericea Lespedeza (Lespedeza cuneata G. Don)" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 41(11): 1508~1514     
    62. Lee, Soo-Jung ; Shin, Jung-Hye ; Kang, Jae-Ran ; Hwang, Cho-Rong ; Sung, Nak-Ju 2012. "In vitro Evaluation of Biological Activities of Wa-song (Orostachys japonicus A. Berger) and Korean Traditional Plants Mixture" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 41(3): 295~301     
    63. Sung, Yung-Wei ; Lee, Ji-Hyun ; Song, Kyoo-Ju ; Koo, Byung-Soo ; Kim, Geun-Woo 2012. "Preventive Effects of Santalum album L. Extracts on Oxidation, Platelet Aggregation and Thrombosis" 동의신경정신과학회지 = Journal of oriental neuropsychiatry, 23(1): 115~128     
    64. Kwon, Ji-Wung ; Lee, Hee-Kwon ; Park, Hee-Jeon ; Song, Ji-Young 2012. "Physiological Activities of Rubus coreanus Miq. Extracts Using Different Extraction Methods" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 28(1): 25~32     
    65. Lee, Youn-Ri ; Kim, Ki-Youn ; Lee, Sang-Hoon ; Kim, Min-Young ; Park, Hye-Jin ; Jeong, Heon-Sang 2012. "Antioxidant and Antitumor Activities of Methanolic Extracts from Humulus japonicus" 한국식품영양학회지 = The Korean journal of food and nutrition, 25(2): 357~361     
    66. Jeong, Sang-Yeol ; Lee, Sook-Young 2013. "The characteristics of Quality and Anti-oxidation of Brown Rice Jeung-pyun Dough Containing Different Amounts of Acorn Flour" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 29(6): 749~760     
    67. Kim, Ji Seon ; Kim, Ji Woong ; Kwon, Hee Seok ; Lim, Hye Won ; Lee, Hyeon Yong 2013. "Screening of Skin Whitening Activity of Codonopsis lanceolata Extract by Complex Steaming Process" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 21(1): 54~60     
    68. Kim, Ji Seon ; Choi, Woo Seok ; Chung, Jae Youn ; Chung, Hee Chul ; Lee, Hyeon Yong 2013. "Enhancement of Cosmeceutical Activity from Codonopsis lanceolata Extracts by Stepwise Steaming Process" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 21(3): 204~212     
    69. Byun, Myung-Woo 2013. "Immunomodulatory Activities of Apple Seed Extracts on Macrophage" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 42(9): 1513~1517     
    70. Kim, Song-Suk 2014. "A Comparison of Antioxidant Effects among Non-fermented and Fermented Columbian Coffee, and Luwak Coffee Beans" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 30(6): 757~766     
    71. Choi, Woon Yong ; Lee, Hyeon Yong 2014. "Enhancement of Antioxidant Activities of Curcuma longa Leaves by Ultra High Pressure Extraction" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 22(2): 121~126     
    72. Lee, Ji-Na ; Kim, Hyeong-Eun ; Kim, Yong-Suk 2014. "Anti-diabetic and Anti-oxidative Effects of Opuntia humifusa Cladodes" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 43(5): 661~667     
    73. Cho, MyoungLae ; Lee, Jong Seok ; Lee, Sarah ; Son, Youn Kyoung ; Bae, Chang-Hwan ; Yeo, Joohong ; Lee, Hae-Sock ; Ma, Jin-Gyeong ; Lee, Ok-Hwan ; Kim, Jong-Yae 2015. "Antioxidant Activity of 11 Species in Korean Native Forest Plants" 한국식품영양학회지 = The Korean journal of food and nutrition, 28(6): 1098~1106     
    74. Kim, Han Soo ; Yun, Hyun 2015. "The Antioxidant Effect of Cheonggukjang, Fermented Using the New Strain, Bacillus amyloliquefaciens NBF11-1" 한국산학기술학회논문지 = Journal of the Korea Academia-Industrial cooperation Society, 16(8): 5343~5350     
    75. Choi, Weon-Young ; Cho, Kwang-Min ; Kim, Sun ; Jeong, Jae-Hyeok ; Lee, Su-Hwan ; Lee, Kyeong-Bo ; Lee, Geon-Hwi ; Park, Ki-Hun 2015. "Effect of PE Film Mulching and Irrigation Method on the Growth, Yield and Antioxidant Activity for Potatoes Grown in Winter Season at Saemangeum Reclaimed Land" Korean journal of crop science = 韓國作物學會誌, 60(1): 63~69     
    76. Kim, Su-Gyeong ; Byun, Hoo-Dhon ; Kim, Sang Cheol ; Yang, Kyong-wol ; Kim, Jeong Hee ; Han, Jong-Heon 2015. "Antioxidative and Anti-inflammatory Activities of Carrot flower" KSBB Journal, 30(2): 77~81     
    77. Lee, Hye Ja ; Kim, Gi Ok ; Park, Jin Oh ; Joo, Chul Gue 2015. "A Study on the Biological Activities of Wild Mushroom Extracts from Jeju Island" 大韓化粧品學會誌 = Journal of the society of cosmetic scientists of Korea, 41(2): 165~172     
    78. Lee, Youn Ri ; Yoon, Nara 2015. "Anti-Oxidative and Anti-Diabetic Effects of Methanol Extracts from Medicinal Plants" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 44(5): 681~686     
    79. Chung, Hai-Jung 2015. "Comparative study of antioxidant activity of imported tropical and subtropical fruits" 한국식품저장유통학회지 = Korean journal of food preservation, 22(4): 577~584     
    80. Park, Jae Ho ; Jang, Tae Won ; Lee, Seung Hyun 2016. "Antioxidative Activities and Inhibition Effects on Oxidative DNA Damage of Valeriana fauriei" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 24(6): 464~470     
    81. Kim, Han Soo 2016. "The Antimicrobial Activity of Cheonggukjang, Using the New Strain, Bacilllus amyloliquefaciens NBF11-1 Extract and Their Heat and pH Stabilities" 한국산학기술학회논문지 = Journal of the Korea Academia-Industrial cooperation Society, 17(7): 442~450     
    82. Lee, In Gyeong ; Min, Seo Cheol ; Kim, Hee Sun ; Han, Gwi Jung ; Kim, Myung Hwan 2016. "Quality Deterioration Suppressing Effects of pH Regulators during Heat Treatment of Concentrated Blueberry Puree" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 32(5): 549~558     

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