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꾸지뽕나무로부터 항균성 Prenylated Flavonoids의 분리
Isolation of Antibacterial Prenylated Flavonoids from Cudrania tricuspidata

이병원   (경상대학교 농화학과UU0000114  ); 강남숙   (경상대학교 농화학과UU0000114  ); 박기훈   (경상대학교 농화학과UU0000114  );
  • 초록

    꾸지뽕나무(Cudrania tricuspidata Bureau)의 클로로포름 추출물로부터 2종의 prenylated flavonoid 항균 물질을 분리하였다. 분리할 화합물에 대하여 항균활성을 실험 한 결과 화합물 1과 2는 $10\;{\mu}g/disk$ 의 농도에서 Gram 양성균인 Staphylococcus aureus, Bacillus subtilis 그리고 Bacillus cereus에 대하여 활성을 보였다. 이들의 구조를 $^lH\;NMR,\;^{13}C\;NMR$ 및 2D NMR을 포함한 분광학적인 방법을 통하여 분석한 결과, 화합물 1과 2는 euchrestaflavanone B와 euchrestaflavanone C로 각각 동정 되었다.


    Two prenylated flavonoids were isolated from a chloroform extract of the root bark of Cudrania tricuspidata. Both compounds (1, 2) showed antibacterial activity against Gram positive bacteria, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. Their structures were determined as euchrestaflavanone B (1) and euchrestaflavanone C (2) on the basis of $^1H\;NMR,\;^{13}C\;NMR$ and long-range coupling NMR techniques.


  • 주제어

    꾸지뽕나무 .   항균활성.  

  • 참고문헌 (19)

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    6. Kang, D. G., Hur, T. Y., Lee, G. M., Oh, H. C., Kwon, T. O., Sohn, E. J. and Lee, H. S. (2002) Effects of Cudrania tricuspidata water extract on blood pressure and renal functions in NO-dependent hypertension. Life Sci. 70, 2599-2609 
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  • 이 논문을 인용한 문헌 (9)

    1. Oh, Sang-Seok ; Seo, Eun-Jin ; Kim, Hoi-Young ; Ryu, Young-Bae ; Lee, Jin-Hwan ; Gal, Sang-Wan ; Park, Ki-Hun 2007. "Tyrosinase Inhibitory Xanthones from Cudrania tricuspidata" 생명과학회지 = Journal of life science, 17(4): 476~481     
    2. Choi, So-Ra ; You, Dong-Hyun ; Kim, Jong-Yeob ; Park, Chun-Bong ; Kim, Dae-Hyang ; Ryu, Jeong ; Choi, Dong-Geun ; Park, Hyun-Mi 2009. "Antimicrobial Activity of Methanol Extracts from Cudrania tricuspidata Bureau according to the Parts Harvested and Time" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 17(5): 335~340     
    3. Choi, So-Ra ; You, Dong-Hyun ; Kim, Jong-Yeob ; Park, Chun-Bong ; Kim, Dae-Hyang ; Ryu, Jeong 2009. "Antioxidant Activity of Methanol Extracts from Cudrania tricuspidata Bureau according to Harvesting Parts and Time" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 17(2): 115~120     
    4. Kim, Soo-Hyun ; Chung, Mi-Ja ; Jang, Hae-Dong ; Ham, Seung-Shi 2010. "Antioxidative Activities of the Codonopsis lanceolata Extract in vitro and in vivo" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 39(2): 193~202     
    5. Cho, Young-Du ; Han, Hyo-Sang ; Lee, Young-Jong 2010. "Inhibitory Effect of Cudraniae Tricuspidatae Radix on Collagen-induced Arthritis in Mice" 大韓本草學會誌 = The Korea journal of herbology, 25(4): 137~143     
    6. Lee, Hye-Jin ; Do, Jeong-Ryong ; Kwon, Joong-Ho ; Kim, Hyun-Ku 2011. "Physiological Activities of Extracts from Different Parts of Cudrania tricuspidata" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 40(7): 942~948     
    7. Sung, Gyoo Byung ; Kim, Ki Young ; Kim, Hyun Bok ; Ji, Sang Duk 2012. "Optimal Cutting Conditions for the Production of Cudriania tricuspidata Bureau" 한국잠사곤충학회지 = Journal of sericultural and entomological science, 50(2): 166~170     
    8. Nam, Da-Eun ; Kim, Ok Kyung ; Lee, Jeongmin 2013. "Therapeutic Effects of Curdrania tricuspidata Leaf Extract on Osteoarthritis" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 42(5): 697~704     
    9. Choi, Hak Joo ; Kim, Cheong Taek ; Do, Min Yeon ; Rang, Moon Jeong 2015. "Physiological Activities of Cudrania tricuspidata Extracts on the Skin" 한국유화학회지 = Journal of oil & applied science, 32(2): 260~274     

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