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The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology v.12 no.4, 2004년, pp.198 - 201  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Neurochemical Alterations in Physical Dependence on Butorphanol

Ho, I. K.    (Department of Pharmacology and Toxicology, University of Mississippi Medical Center   ); Fan, Lir-Wan    (Department of Pharmacology and Toxicology, University of Mississippi Medical Center   ); Kim, Seong-Youl    (Department of Pharmacology and Toxicology, University of Mississippi Medical Center   ); Ma, Tangeng    (Department of Pharmacology and Toxicology, University of Mississippi Medical Center   ); Rockhold, Robin W.    (Department of Pharmacology and Toxicology, University of Mississippi Medical Center  );
  • 초록

    This review focuses on finding neurochemical changes in physical dependence on butorphanol, a relatively potent mixed agonist-antagonist opioid analgesic agent that is five times more potent than morphine in antinociceptive effects. The chronic administration of butorphanol induces physical dependence. Withdrawal from such dependence can be reliably precipitated by administration of a narcotic antagonist, e.g., naloxone. Evidence for critical involvement of excitatory aminoacid (glutamate), opioid receptors, and phosphorylation of proteins in these phenomena is summarized.


  • 주제어

    Butorphanol .   Physical dependence .   glutamate .   opioid receptors .   phosphotyrosyl proteins.  

  • 참고문헌 (32)

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