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The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology v.12 no.4, 2004년, pp.202 - 208   피인용횟수: 1
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Diabetes, Glucose Transport and Hypoglycaemic Agents

Khil, Lee-Yong    (Faculty of Medicine, University of Calgary  );
  • 초록

    Diabetes mellitus is a complex metabolic derangement with hyperglycaemia being the most characteristic symptom of diabetes. Hyperglycaemia can be caused by an increase in the rate of glucose production by the liver or by a decrease in the rate of glucose use by peripheral tissues. Impaired glucose transport is one of the major factors contributing to insulin resistance in type 2 diabetic patients. The ability of insulin to mediate tissue glucose uptake is a critical step in maintaining glucose homeostasis and in clearing the post-prandial glucose load. Glucose transport is mediated by specific carriers called glucose transporters (GLUTs). In this article, the functional importance and molecular mechanisms of insulin-induced glucose transport and development of hypoglycaemic agents which increase glucose transport are reviewed.

  • 주제어

    diabetes .   glucose transport .   hypoglycemic agent .   insulin .   phophatitylinositol 3-kinase .   TC10.  

  • 참고문헌 (70)

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