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The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology v.12 no.4, 2004년, pp.235 - 241  
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Regulatory Effect of Atopic Allergic Reaction by Modified Gagam-danguieumja

Na, Ho-Jeong    (College of Oriental Pharmacy, Wonkwang University, College of Oriental Medicine, Kyung Hee University   ); Kwon, Dong-Yeul    (College of Oriental Pharmacy, Wonkwang University   ); Kim, Hyung-Min    (College of Oriental Medicine, Kyung Hee University   ); Park, Eun-Jeong    (College of Oriental Medicine, Wonkwang University   ); Lee, Eun-Hee    (Division of Beauty Arts, Jeonbuk Science College   ); Hong, Seung-Heon    (College of Oriental Pharmacy, Wonkwang University  );
  • 초록

    Gagam-danguiemja (GDGJ), a traditional Korean prescription, has been used as therapeutics for atopic allergic diseases such as atopic dermatitis. To evaluate the atopic allergic effect of modified GDGJ, we investigated a possible effect of GDGJ on mast cell-mediated allergic reaction, cytokinases secretion and mRNA expression in vivo and in vitro. Mast cells are a potent source of mediators that regulate the inflammatory response in allergic reaction. In mice orally administered by GDGJ (0.01, 0.1 and 1.0 g/kg) for 1 h, compound 48/80-induced ear oedema was significantly reduced. TNF- ${\alpha}$ , IL-8, and IL-6 secretion were inhibited by GDGJ in the human mast cell line (HNC-1). But TNF- ${\alpha}$ , IL-8, and IL-6 mRNA expression were not inhibited by GDGJ at the dose of 0.01 mg/ml. These findings may help in understanding the mechanism of action of this herbal medication, leading to the control of mast cells in atopic allergic reaction like AD.


  • 주제어

    Gagam-danguiemja .   atopic allergic reactions .   mast cell .   cytokine.  

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