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大韓獸醫學會誌 = Korean journal of veterinary research v.44 no.4 = no.117, 2004년, pp.483 - 486  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

A potential role of Schwann cells in spinal nerve roots in autoimmune central nervous system diseases

Moon, Changjong    (Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University   ); Lee, Yongduk    (Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University   ); Shin, Taekyun    (Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University  );
  • 초록

    The expression of nestin and vimentin in the spinal nerve roots of rats with experimental autoimmune encephalomyelitis (EAE) was studied to ascertain whether Schwann cells in the peripheral nerves respond to acute central nervous system autoimmune injury. Immunohistochemistry demonstrated that nestin was constitutively expressed in the dorsal roots of spinal nerves in control rats; its expression was enhanced in the spinal nerve roots of rats with EAE. Vimentin expression was weak in control rat spinal nerve roots, and it was increased in the dorsal roots of rats with EAE. It is postulated that normal animals have multipotent progenitor cells that constitutively express nestin and vimentin in the spinal nerve roots. In response to an injury of the central nervous system, these multipotent Schwann cells are activated in the spinal nerve roots through the expression of the intermediate filament proteins vimentin and nestin.


  • 주제어

    autoimmune encephalomyelitis .   Schwann cells .   nestin .   vimentin.  

  • 참고문헌 (14)

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    4. Moon, C., Kim, S., Wie, M., Kim, H., Cheong, J., Park, J., Jee, Y., Tanuma, N., Matsumoto, Y. and Shin, T. Increased expression of p53 and Bax in the spinal cords of rats with experimental autoimmune encephalomyelitis. Neurosci. Lett. 2000, 289, 41-44 
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    11. Shin, T., Kojima, T., Tanuma, N., Ishihara, Y. and Matsumoto, Y. The subarachnoid space as a site for precursor T cell proliferation and effector T cell selection in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 1995, 56, 171-178 
    12. Dijkstra, C. D., Dopp, E. A., Joling, P. and Kraal, G. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology 1985, 54, 589-599 
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