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Biotechnology and bioprocess engineering v.9 no.5, 2004년, pp.356 - 361   피인용횟수: 4

Effect of Pleurotus ferulae Extracts on Viability of Human Lung Cancer and Cervical Cancer Cell Lines

Choi DuBok    (Department of Chemical Engineering, Chosun University   ); Cha Wol-Suk    (Department of Chemical Engineering, Chosun University   ); Kang Si-Hyung    (Department of Chemical Engineering, Chosun University   ); Lee Byoung-Rai    (Department of Biochemistry, College of Medicine, Chosun University  );
  • 초록

    When SiHa cells were incubated for varying periods of time with extracts of PFF and PFM, the cytotoxicity of the ethanol extracts of PFF was higher than those of the other extracts. These results indicated that the extracts from fruiting bodies of p. ferulae contain antitumor Substances. When A549, SiHa and HeLa cells were incubated with different concentrations of PFF and PFM extracts, the ethanol extracts of PFF showed strong cytotoxicity against A549 tells at concentrations over $10{\mu}g/mL$ and against SiHa and HeLa cells at concentrations over $40{\mu}g/mL$ . However, the differences in the cytotoxic effects of the hot water and ethanol extracts of PFM and the hot water extracts of PFF on all 3 cancer cells were not significant. Also, the PFF ethanol extracts induced synergistic effects on the TRAIL-induced apoptosis in A549 cells, which were strongly resistant to TRAIL. These results indicated that ethanol extracts of PFF were the most prominent antitumor agents toward lung cancer cells (A549).


  • 주제어

    Pleurotur ferulae .   human lung cancer .   cervical cancer cell line.  

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  • 이 논문을 인용한 문헌 (4)

    1. 2007. "" Biotechnology and bioprocess engineering, 12(2): 100~105     
    2. 2007. "" Biotechnology and bioprocess engineering, 12(5): 516~524     
    3. 2009. "" Biotechnology and bioprocess engineering, 14(2): 232~237     
    4. Choi, Hyung-Wook ; Kim, Eun-Joo ; Kim, Keun-Ki ; Shin, Pyung-Gyun ; Kim, Gun-Do 2016. "Anti-inflammatory properties of chloroform extracts from GW10-45, a new cultivar derived from Pleurotus ferulae, in RAW264.7 murine macrophages." Journal of mushrooms = 한국버섯학회지, 14(4): 220~224     

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