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약학회지 = Yakhak hoeji v.48 no.1, 2004년, pp.55 - 59   피인용횟수: 3

화상 및 창상 치료용 외용제제 개발에 대한 기초 연구
Studies on the Wound Healing by the PVA-soft hydrogel

조동현   (경성대학교 약학대학UU0000115  ); 신영희   (경성대학교 약학대학UU0000115  );
  • 초록

    A PVA-soft hydrogel, which is a semi-solid form in container, whereas after applying on the skin, it formed a thin layer within a few minutes. In this study, we prepared a novel type PVA-soft hydrogel containing 6-methyluracil as active drug, and the therapeutic value was characterized. To evaluate the therapeutic value of the PVA-soft hydrogel containing drug, various animal models, thermal burn model, incision & excision wound rat model were used. We also measured the wound size and breaking strength to calculate the wound healing extent after single or multiple administration. The wound size of soft hydrogel treated group decreased rapidly than that of control group after multiple dosing in excision wound model. And, the breaking strength of the soft hydrogel treated group was greater than that of control group in incision wound model.


  • 주제어

    soft-hydrogel .   wound healing .   thermal burn model .   incision & excision wound model.  

  • 참고문헌 (20)

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    6. Adverse dermatologic reaction to transdermal nitroglycerin , Letendre,P.W.;Barr,C.;Wilkens,K. , Drug Intell. Clin. Pharm. / v.18,pp.69,
    7. U75412E, a lazaroid, prevents progressive burn ischemia in a rat burn model , Choi,M.;Ehrlich,H.P. , Am. J. Pathol. / v.142,pp.519,
    8. Anti-inflammatory Activity of Ketoprofen Soft Hydrogel. , Lee,E.K.;Shin,Y.H.;Lee,C.H. , J. Kor. Pharm. Sci. / v.29,pp.137,
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    16. Influence of naproxen on the healing of open excision wound in rats , Margaret,I.;Jamil,K. , Biomed. Sci. Instrum. / v.33,pp.226,
    17. Effects OR 6-methyl-uracil upon the phargocytic activity in mice following whole-body X-irradiation OR 2,4,6-triethyleneimino-s-triazine treatment , Raake,W.;Temple,K. , Strahlentherapie / v.153,pp.843,
    18. A new drug delivery system with controlled release of antibiotic only in the presence of infection , Suzuki,Y.;Tanihara,M.;Nishimura,Y.;Suzuki,K.;Kakimaru,Y.;Shimizu,Y. , J. Biomed. Mater. Res. / v.42,pp.112,
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    20. Transderm Scop for prevention of motion sickness , Johnson,P.;Hansen,D.;Matarazzo,D.;Petterson,L.;Swisher,C.;Trappolini,A. , N. Engl. J. Med. / v.311,pp.468,
  • 이 논문을 인용한 문헌 (3)

    1. Min, Dong-Hoon ; Kim, Dae-Keun ; Lim, Jong-Pil ; Yang, Jae-Heon 2005. "Transdermal Drug Delivery & Therapeutic Effect of the Preparations of Lithospermi Radix and Gardeniae Fructus Extracts on the Burn & Wound Healing" 藥劑學會誌 = Journal of Korean pharmaceutical sciences, 35(4): 255~263     
    2. Oh, Seung-Seok ; Kim, Chul-Jun ; Kim, Hee-Sook ; Shin, Young-Hee 2009. "Efficacy of Hydrogel Patch in Wound Rat Model" 藥劑學會誌 = Journal of Korean pharmaceutical sciences, 39(1): 55~58     
    3. Song, Beom-Yong ; Lee, Chang-Hyun 2009. "Effects of the Acupuncture or Pharmacopunture Treatment for the Histologic and Morphologic Recovery on the Mouse with the Burn Skin" 大韓鍼灸學會誌= The journal of Korean Acupuncture & Moxibustion Society, 26(3): 81~92     

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    1. 1990 "Barbiturates가 소의 신선한 대뇌피질 Synaptosomal Plasma Membrane Vesicles로 부터 추출하여 제제한 Phosphatidylethanolamine 인공세포막의 유동성에 미치는 영향" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 26 (2): 209~217    
    2. 1990 "대두 지방산을 활용한 화장품 기초제 개발" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 20 (2): 55~64    
    3. 1991 "Studies on Corneal Penetration of P-Hydroxybenzoic Acid Esters" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 14 (4): 311~318    
    4. 1992 "Effects of Barbiturates on the Rotational Relaxation Time of 1, 6-Diphenyl-1, 3, 5-hexatriene in Native and Model Membranes" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 15 (4): 298~303    
    5. 1994 "토끼의 각막 추출액 중 메치오닌엔케팔린 및 [D-알라$^2$-메치오닌엔케팔린아미드의 분해 및 안정화" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 24 (1): 1~9    
    6. 1995 "Effects of Calcium Channel Blockers on Human Erythrocyte Ghost Membranes" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 18 (6): 402~409    
    7. 1998 "서방출성 리오겔 연고의 물리적성질과 방출특성" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 28 (1): 51~57    
    8. 1999 "케토푸로펜 소프트 히드로겔의 항염증효과" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 29 (2): 137~143    
    9. 1999 "티니다졸의 제어방출을 위한 새로운 합성고분자성 정제의 조성" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 29 (4): 349~353    
    10. 2000 "Soybean Trypsin Inhibitor와 황산 콘드로이친 포합체의 약리 효과 평가" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 30 (3): 159~166    

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