근적외분광분석법을 사용한 암브록솔 정제의 비파괴적 정량분석
Nondestructive Quantification of Intact Ambroxol Tablet using Near-infrared Spectroscopy
Near-infrared (NIR) spectroscopy was used to determine rapidly and nondestructively the content of ambroxol in intact ambroxol tablets containing 30 mg (12.5% m/m nominal concentration) by collecting NIR spectra in range 1100-1750 nm. The laboratory-made samples had 10.3∼15.9% m/m nominal ambroxol concentration. The measurements were made by reflection using a fiber-optic probe and calibration was carried out by partial least square regression (PLSR) with autoscaling. Model validation was performed by randomly splitting the data set into calibration and validation data set (7 samples as a calibration data set and 5 samples as a validation data set). The developed NIR method gave results comparable to the known values of tablets in a laboratorial manufacturing Process, standard error of calibration (SEC) and standard error of prediction (SEP) being 0.49% and 0.49% m/m respectively. The method showed good accuracy and repeatability NIR spectroscopic determination in intact tablets allowed the potential use of real time monitoring for a running production process.
Near infrared reflectance analysis: features and applications in pharmaceutical and biomedical analysis ,
Farmaco / v.48,pp.3,
Rapid near-infrared spectroscopic method for determination of meprobamate in meprobamate tablets ,
J. Assoc Off. Anal. Chem. / v.51,pp.,
Strategies for constructing the calibration set in the determination of active principles in pharmaceuticals by near infrared diffuse reflectance spectroscopy ,
Analyst / v.122,pp.761,
Some applications of near-infrared reflectance analysis in the pharmaceutical industry ,
J. Pharm. Biomed. Anal. / v.11,pp.1077,
Quantitation of the active compound and major excipients in a pharmaceutical formulation by near infrared diffuse reflectance spectroscopy with fibre optical probe ,
Anal. Chim. Acta / v.333,pp.147,
Near-infrared spectroscopy: applications in the analysis of tablets and solid pharmaceutical dosage forms ,
Pharm. Sci. / v.3,pp.447,
Detection of capsule tampering by near-infrared reflectance analysis ,
Anal. Chem. / v.59,pp.1921,
Near-infrared spectroscopy in the pharmaceutical industry ,
Analyst / v.123,pp.135R,
A rapid quantitative assay of intact paracetamol tablets by reflectance near-infrared spectroscopy ,
Analyst / v.124,pp.163,
Near-infrared analytical control of pharmaceuticals. A single calibration model from mixed phase to coated tablets ,
Analyst / v.123,pp.2307,
- Near infrared reflectance analysis: features and applications in pharmaceutical and biomedical analysis , Corti,P.;Dreassi,E.;Lonardi,S. , Farmaco / v.48,pp.3,
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