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韓國營養學會誌 = The Korean journal of nutrition. v.37 no.4, 2004년, pp.259 - 265   피인용횟수: 2

동과 종자의 섭취가 Streptozotocin 유발 당뇨 흰쥐의 혈당 및 혈장 지질수준에 미치는 영향
Effects of Benincasa hispida Seeds Intake on Blood Glucose and Lipid Levels in Streptozotocin Induced Diabetic Rats

임숙자   (덕성여자대학교 자연과학대학 식품영양학과UU0000446  ); 김예리   (덕성여자대학교 자연과학대학 식품영양학과UU0000446  );
  • 초록

    본 연구는 220 g 내외의 Sprague-Dawley계 수컷 흰쥐를 이용하여 정상군, 당뇨대조군, 동과 종자 2.5% 섭취군 및 동과 종자 5.0% 섭취군으로 구분하여 실험하였다. 동과 종자의 첨가량을 각각 2.5%와 5.0%로 달리하여 4주 동안 섭취시킨 후 혈장 중의 포도당과 지질함량에 미치는 영향을 검토하였다. 당뇨대조군에 비해 동과 종자 5.0%를 섭취한 군에서는 4주 후의 체중이 초기에 비하여 7.4% 증가함을 볼 수 있었다. 혈당 수준은 실험 1주째부터 당뇨대조군에 비해 당뇨실험군이 유의적으로 감소하기 시작하여 실험 4주 후에는 유의적으로 감소되었다. 혈장 콜레스테롤 수준은 동과 종자 5.0%를 섭취한 군에서 실험 1주째부터 유의적으로 낮아지기 시작하여 실험 4주째까지 그 수준을 유지하였다. 혈장 중의 HDL -cholesterol, 중성지방 및 유리지방산 수준은 정상군에 비해 당뇨대조군에서 유의적으로 높게 나타났고, 혈장 중성지방 수준에서는 당뇨대조군에 비해 종자 2.5% 섭취군에서 유의적으로 낮게 나타났다. AST 활성도는 정상군과 당뇨유발군간의 유의적인 차이가 나타나지 않았고, ALT 활성도는 정상군에 비해 당뇨대조군에서 유의적으로 높게 나타났다. 이상의 실험결과 동과 종자 2.5%와 5.0%의 섭취가 streptozotocin 유발 당뇨 쥐에서 혈당강하 효과를 보였을 뿐만 아니라 2.5% 섭취에서는 지질함량을 저하시키는 효과도 있는 것으로 보여졌다.


    This study was designed to examine the effects of diets containing different levels of seeds of Benincasa hispida (wax-gourd)on plasma glucose, insulin levels and lipid profiles in streptozotocin (STZ)-induced diabetic rats. Sprague-Dawley rats were induced diabetes mellitus by STZ injection (45 mg/kg) into the tail vein and were divide into 4 groups: normal, STZ-control, two experimental groups. Normal and STZ-control groups were fed an AIN-93 diet and 2 experi-mental groups were fed a modified diet containing 2.5% and 5.0% of wax gourd seed powder for 4 weeks. The weight gain and feed efficiency ratio in 5.0% seed groups were higher than in STZ-control group. A significant lowering effects of plasma glucose levels were observed in the wax gourd seed 2.5% and 5.0 groups. The plasma insulin level did not differ after treatment with wax gourd seed in experimental rats. The intake of 2.5% wax gourd seed did not result in sig-nificant change in plasma cholesterol levels compared to diabetic control group. The intake of 2.5% wax gourd seeds had normalized the increased levels of plasma triglyceride and free fatty acids after 4 weeks. In 5% wax gourd seed group, cholesterol, triglyceride and free fatty acid levels were elevated compared to 2.5% wax gourd seed group. The results of the present study indicate that 2.5% wax gourd seed group would be more effective to control the diabetes than 5% wax gourd seed group.


  • 주제어

    Benincasa hispida (wax gourd) seeds .   diabetic rats .   hypoglycemic effect .   triglyceride level.  

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  • 이 논문을 인용한 문헌 (2)

    1. Kim Han-Soo 2004. "Effects of the Prunus persica Batsch var. davidiana Max. Extract on the Blood Glucose and Serum Lipid Components in Streptozotocin-Induced Diabetic Rats" 한국식품영양학회지 = The Korean journal of food and nutrition, 17(3): 337~345     
    2. Kim, Han-Soo ; Seong, Jong-Hwan ; Lee, Young-Guen ; Xie, Cheng-Liang ; Shin, Ji-Moon ; Yoon, Ho-Dong 2010. "Improvements Caused by Silk Sericin Extract Derived from Silkworm in Blood Glucose and Lipid Concentration in Diabetic Rats" 한국식품영양학회지 = The Korean journal of food and nutrition, 23(3): 392~398     

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