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Synthesis and Study of Antibacterial and Antifungal Activities of Novel 2-[[(Benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles

Kaplancikli, Zafer-Asim    (Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry   ); Gulhan, Turan-Zitouni    (Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry   ); Revial, Gilbert    (Laboiratoire de Chimie Organique, CNRS (ESA 7084) ESPCI   ); Guven, Kiymet    (Anadolu University, Faculty of Science, Department of Biology  );
  • 초록

    Several 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles derivatives were synthesized by reacting 4-substituted-2-(chloroacetylamino)thiazoles with benzoxazole/benzimidazole-2-thioles in acetone and in the presence of $K_2CO_3$ . The chemical structures of the compounds were elucidated by IR, $^1H-NMR$ , and $FAB^{+}-MS$ spectral data. Their antimicrobial activities against Micrococcus luteus (NRLL B-4375), Bacillus cereus (NRRL B-3711), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (NRRL B-4420), Staphylococcus aureus (NRRL B-767), Escherichia coli (NRRL B-3704), Candida albicans and Candida globrata (isolates obtained from Osmangazi Uni. Fac.of Medicine) were investigated and in this investigation, a significant level of activity was illustrated.


  • 주제어

    Thiazole .   Benzoxazole .   Benzimidazole .   Antimicrobial activity.  

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  • 이 논문을 인용한 문헌 (2)

    1. 2011. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 34(7): 1077~1084     
    2. 2011. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 34(9): 1427~1435     

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