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Synthesis and Antinociceptive Activity of (5-Chloro-2(3H)-Benzoxazolon-3-yl) Propanamide Derivatives

Onkol, Tijen    (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University   ); Sahin, M.Fethi    (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University   ); Yidirim, Engin    (Department of Pharmacology, Faculty of Medicine, Osmangazi University   ); Erol, Kevser    (Department of Pharmacology, Faculty of Medicine, Osmangazi University   ); Ito, Shigero    (Institute for Medicinal and Dental Engineering, Tokyo Medicinal and Dental University  );
  • 초록

    In this study, (5-chloro-2(3H)-benzoxazolon-3-yl)propanamide derivatives were synthesized. The chemical structures of the compounds were elucidated by their IR and $^1H-NMR$ spectral data and microanalysis. The compounds were tested for anti nociceptive activity by using the tail clip, tail flick, hot plate, and writhing methods. The varying levels of anti nociceptive activity of the compounds were compared with those of dipyrone and aspirin. Among these compounds, compound 5e, 5g, and 5h have been found to be significantly more active than the others and the standards in all the tests.


  • 주제어

    5-Chloro-2(3H)-benzoxazolone .   (5-Chloro-2(3H)-benzoxazolon-3-yl)propanamide .   Antinociceptive activity.  

  • 참고문헌 (30)

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  • 이 논문을 인용한 문헌 (1)

    1. 2007. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 30(7): 803~811     

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