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Protective Constituents Against Sepsis in Mice from the Root Cortex of Paeonia suffruticosa

Li, Gao    (College of Pharmacy, Yanbian University   ); Seo, Chang-Seob    (College of Pharmacy, Yeungnam University   ); Lee, Kyeung-Seon    (College of Pharmacy, Yeungnam University   ); Kim, Hyo-Jin    (College of Pharmacy, Yeungnam University   ); Chang, Hyun-Wook    (College of Pharmacy, Yeungnam University   ); Jung, Jun-Sub    (Department of Pharmacology, Hallym University College of Medicine, Institute of Natural Medicine   ); Song, Dong-Keun    (Department of Pharmacology, Hallym University College of Medicine, Institute of Natural Medicine   ); Son, Jong-Keun    (College of Pharmacy, Yeungnam University  );
  • 초록

    The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root cortex of Paeonia suffruticosa ANDREWS (Ranunculaceae) led to the isolation of eight known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2), acetovanillone (3), paeonoside (4), paeoniflorin (5), oxypaeoniflorin (6), apiopaeonoside (7), and methyl 3-hydroxy-4-methoxybenzoate (8). Among them, 3 showed the highest survival rate (100% with a dose of 30 mg/kg versus 17% for the control experiment) and reduced alanine aminotransferase level to be a half of the control value on the sepsis model induced by lipopolysaccharide/D-galactosamine.


  • 주제어

    Paeonia suffruticosa .   Sepsis .   LPS .   D-GaIN .   ALT.  

  • 참고문헌 (19)

    1. Kawaguchi, K., Kikuchi, S., Hasunuma, R., Maruyama, H., Ryll, R., and Kumazawa, Y., Suppression of infection-induced endotoxin shock in mice by a Citrus flavanone naringin. Planta Med., 70,17-22 (2004) 
    2. Kwon, O. G., Kim, S. H., Chun, B. Y., Park, C. K., and Son, K. H., Isolation of antimicrobial components from moutan cortex. Kor. J. Pharmacogn., 30, 340-344 (1999) 
    3. Novogrodsky, A., Vanichkin, A., Patya, M., Gazit, A., Osherov, N., and Levitzki, A., Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science, 264, 1319-1332 (1994) 
    4. Zhang, H., Peterson, J. W., Niesel, D. W., and Klimpel, G. R., Bacterial lipoprotein and lipopolysaccharide act synergistically to induce lethal shock and proinflammatory cytokine production. J. Immunol., 159, 4868-4878 (1997) 
    5. Kitagawa, I., Yoshikawa, M., Tsunaga, K., and Tani, T., Studies on moutan cortex II. On the chemical constituents. Shoyakugaku Zasshi 33, 171-177 (1979) 
    6. Lee, S. H., Park, J. S., Kim, S. Y., Kim, J. J., and Chung, S. R., Isolation of inhibitory on tyrosinase activity from the bark of Paeonia moutan. Yakhak Hoeji, 42, 353-358, (1998) 
    7. Yan, J. J., Jung, J. S., Lee, J. E., Lee, J., Huh, S. O., Kim, H. S., Jung, K. C., Cho, J. Y., Nam, J. S., Suh, H. W, Kim, Y. H., and Song, D. K., Therapeutic effects of Iysophosphatidylcholine in experimental sepsis. Nat. Med., 10, 161-167 (2004) 
    8. Kubo, M., Matsuda, H., Izumi, S., Tani, T., Arichi, S., Yoshikawa, M., and Kitagawa, I., Studies on moutan cortex (VI) inhibitory effects on the intravascular coagulation (part I). Shoyakugaku Zasshi, 36, 70-77 (1982) 
    9. Okubo, T., Nagai, F., Seto, T., Satoh, K., Ushiyama, K., and Kano, I., The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan Cortex and Paeoniae Radix. Bio. Pharm. Bull., 23, 199-203 (2000) 
    10. Quideau, S., Pouysegu, L., Oxoby, M., and Looney, M. A., 2-Alkoxyarenol-derived orthoquinols in carbonoxygen, carbon-nitrogen and carboncarbon bond-forming reactions. Tetrahedron, 57, 319-329 (2001) 
    11. Wakabayashi, G., Gelfand, J. A., Jung, W. K., Connolly, R. J., Burke, J. F., and Dinarello, C. A., Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli. J. Clin. Invest., 87, 1925-1935 (1991) 
    12. Herbert, J. M., Fraisse, L., Bachy, A., Valetle, G., Savi, P., Laplace, M. C., Lassalle, J., Roche, B., Lale, A., and Keane, P. E., Biochemical and pharmacological properties of SR 27388, a dual antioxidant and PAF receptor antagonist. J. Lipid. Mediat., 8, 31-51 (1993) 
    13. Chang, H. M. and But, P H., Pharmacology and Applications of Chinese Material Medica. World Scientific, Singapore, (1986) 
    14. Yu, J., Lang, H. Y., and Xiao, P. G., A new compound, apiopaeonoside, isolated from the root of Paeonia suffruticosa. Acta. Pharmaceutica Sinica, 21, 191-197, (1986) 
    15. Arichi, S., Kubo, M., Matshda, H., Tani, T., Tsunaga, K., Yoshikawa, M., and Kitagawa, I., Study on moutan cortex (III), on anti-inflammatory activities. Shoyakugaku Zasshi, 33, 178-184 (1979) 
    16. Crestini, C. and DAuria M., Singlet oxygen in the photo-degradation of lignin models. Tetrahedron, 53, 7877-7888 (1997) 
    17. Altavilla, A., Squadrito, G., Minutoli, L., Deodato, B., Bova, A., Sardella, A., Seminara, P., Passaniti, M., Urna, G., Venuti, S. F., Caputi, A. P., and Squadrito, F, Inhibitory of nuclear factor-kB activation by IRFI 042, protects against endotoxin-induced shock. Cardiovasc. Res., 54, 684-693 (2002) 
    18. Jeong, S. J., Ahn, N. H., and Kim, Y. C., Hyaluronidase inhibitors from moutan cortex radicis. Kor. J. Pharmacogn., 29, 44-47 (1998) 
    19. Lee, S. W, Li, G., Lee, K. S., Jung, J. S., Xu, M. L., Seo, C. S., Chang, H. W., Kim, S. K., Song, D. K., and Son, J. K., Preventive agents against sepsis and new phenylpropanoid glucosides from the fruits of Illicium verum. Planta Med., 69, 861-864 (2003) 
  • 이 논문을 인용한 문헌 (5)

    1. Choi, Moo-Young ; Park, Hee-Juhn 2005. "In vitro Atiinflmmatory Activity of Paeonol from the Essential Oil and Its Derivative Methylpaeonol" 생약학회지, 36(2): 116~120     
    2. 2008. "" Natural product sciences, 14(3): 202~205     
    3. Lee, Jae-Woong ; Kim, Young-Hwa ; Ko, Byoung-Seob ; Ryuk, Jin-Ah ; Oh, Seung-Eun ; Park, Sang-Un ; Lee, Mi-Young 2010. "ITS-PCR Analysis for the Discrimination of Moutan Cortex" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 18(1): 40~45     
    4. 2011. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 34(9): 1443~1450     
    5. Seo, Chang-Seob ; Shin, Hyeun-Kyoo 2016. "Quantification of the 25 Components in Onkyung-Tang by Ultra Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry" 생약학회지, 47(1): 92~101     

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  • 정전섭 (6)

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