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Protective Constituents Against Sepsis in Mice from the Root Cortex of Paeonia suffruticosa

Li, Gao    (College of Pharmacy, Yanbian University   ); Seo, Chang-Seob    (College of Pharmacy, Yeungnam University   ); Lee, Kyeung-Seon    (College of Pharmacy, Yeungnam University   ); Kim, Hyo-Jin    (College of Pharmacy, Yeungnam University   ); Chang, Hyun-Wook    (College of Pharmacy, Yeungnam University   ); Jung, Jun-Sub    (Department of Pharmacology, Hallym University College of Medicine, Institute of Natural Medicine   ); Song, Dong-Keun    (Department of Pharmacology, Hallym University College of Medicine, Institute of Natural Medicine   ); Son, Jong-Keun    (College of Pharmacy, Yeungnam University  );
  • 초록

    The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root cortex of Paeonia suffruticosa ANDREWS (Ranunculaceae) led to the isolation of eight known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2), acetovanillone (3), paeonoside (4), paeoniflorin (5), oxypaeoniflorin (6), apiopaeonoside (7), and methyl 3-hydroxy-4-methoxybenzoate (8). Among them, 3 showed the highest survival rate (100% with a dose of 30 mg/kg versus 17% for the control experiment) and reduced alanine aminotransferase level to be a half of the control value on the sepsis model induced by lipopolysaccharide/D-galactosamine.

  • 주제어

    Paeonia suffruticosa .   Sepsis .   LPS .   D-GaIN .   ALT.  

  • 참고문헌 (19)

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    6. Lee, S. H., Park, J. S., Kim, S. Y., Kim, J. J., and Chung, S. R., Isolation of inhibitory on tyrosinase activity from the bark of Paeonia moutan. Yakhak Hoeji, 42, 353-358, (1998) 
    7. Yan, J. J., Jung, J. S., Lee, J. E., Lee, J., Huh, S. O., Kim, H. S., Jung, K. C., Cho, J. Y., Nam, J. S., Suh, H. W, Kim, Y. H., and Song, D. K., Therapeutic effects of Iysophosphatidylcholine in experimental sepsis. Nat. Med., 10, 161-167 (2004) 
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  • 이 논문을 인용한 문헌 (5)

    1. Choi, Moo-Young ; Park, Hee-Juhn 2005. "In vitro Atiinflmmatory Activity of Paeonol from the Essential Oil and Its Derivative Methylpaeonol" 생약학회지, 36(2): 116~120     
    2. 2008. "" Natural product sciences, 14(3): 202~205     
    3. Lee, Jae-Woong ; Kim, Young-Hwa ; Ko, Byoung-Seob ; Ryuk, Jin-Ah ; Oh, Seung-Eun ; Park, Sang-Un ; Lee, Mi-Young 2010. "ITS-PCR Analysis for the Discrimination of Moutan Cortex" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 18(1): 40~45     
    4. 2011. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 34(9): 1443~1450     
    5. Seo, Chang-Seob ; Shin, Hyeun-Kyoo 2016. "Quantification of the 25 Components in Onkyung-Tang by Ultra Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry" 생약학회지, 47(1): 92~101     

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  • 정전섭 (6)

  • Song, Dong-Keun (28)

  • Son, Jong-Keun (47)

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