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Acetylcholinesterase Inhibitors from the Aerial Parts of Corydalis speciosa

Kim, Dae-Keun    (College of Pharmacy, Woosuk University   ); Lee, Ki-Taek    (College of Pharmacy, Woosuk University   ); Kim, Sung-Hoon    (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University   ); Park, Hee-Wook    (Department of Oncology, Graduate School of East-West Medical Science, Kyung Hee University   ); Lim, Jong-Pil    (College of Pharmacy, Woosuk University   ); Shin, Tae-Yong    (College of Pharmacy, Woosuk University   ); Eom, Dong-Ok    (College of Pharmacy, Woosuk University   ); Yang, Jae-Heon    (College of Pharmacy, Woosuk University   ); Eun, Jae-Soon    (College of Pharmacy, Woosuk University   ); Baek, Nam-In    (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University  );
  • 초록

    In a bioassay-guided search for acetylcholinesterase inhibitors from Korean natural resources, four isoquinoline alkaloids, corynoxidine (1), protopine (2), palmatine (3), and berberine (4) have been isolated from the methanolic extract of the aerial parts of Corydalis speciosa. Structures of these compounds were elucidated on the basis of spectroscopic techniques. These compounds inhibited acetylcholinesterase activity in a dose-dependent manner, and the $IC_50$ values of compounds 1-4 were 89.0, 16.1, 5.8, and 3.3 $\mu$ M, respectively.


  • 주제어

    Corydalis speciosa .   Acetylcholinesterase .   Isoquinoline alkaloids.  

  • 참고문헌 (19)

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  • 이 논문을 인용한 문헌 (2)

    1. Song, Jung-Eun ; Song, Jung-Hwa ; Cho, Soo-Muk ; Min, Gyung-Hun ; Lee, Jong-Soo 2010. "Nutritional Characteristics and Physiological Functionality of Antidementia Acetylcholinesterase Inhibitor-containing Methanol Extract from Sorghum bicolor" 한국식품영양학회지 = The Korean journal of food and nutrition, 23(2): 226~232     
    2. 2011. "" Natural product sciences, 17(2): 108~112     

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