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Protective Effect of Fermented Red Ginseng on a Transient Focal Ischemic Rats

Bae, Eun-Ah    (College of Pharmacy and Kyung Hee University   ); Hyun, Yang-Jin    (College of Pharmacy and Kyung Hee University   ); Choo, Min-Kyung    (College of Pharmacy and Kyung Hee University   ); Oh, Jin-Kyung    (College of Pharmacy and Kyung Hee University   ); Ryu, Jong-Hoon    (College of Pharmacy and Kyung Hee University   ); Kim, Dong-Hyun    (College of Pharmacy and Kyung Hee University  );
  • 초록

    Red ginseng and fermented red ginseng were prepared, and their composition of ginsenosides and antiischemic effect were investigated. When ginseng was steamed at 98- $100{\circ}C$ for 4h and dried for 5h at $60{\circ}C$ , and extracted with alcohol, its main components were ginsenoside $Rg_3$ > ginsenoside $Rg_1$ $Rg_2$ . When the ginseng was suspended in water and fermented for 5 days by previously cultured Bifidobacterium H-1 and freeze-dried (fermented red ginseng), its main components were compound K > ginsenoside $Rg_3{\geq}$ ginsenoside $Rg_2$ . Orally administered red ginseng extract did not protect ischemia-reperfusion brain injury. However, fermented red ginseng significantly protected ischemica-reperfusion brain injury. These results suggest that ginsenoside Rh2 and compound K, which was found to be at a higher content in fermented red ginseng than red ginseng, may improve ischemic brain injury.


  • 주제어

    Ginseng .   Intestinal bacteria .   Fermented ginseng .   Ischemia.  

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    7. Jo, Eun-Jung ; Kang, Shin-Jung ; Kim, Ae-Jung 2009. "Effects of Steam- and Dry-processing Temperatures on the Benzo(a)pyrene Content of Black and Red Ginseng" 한국식품영양학회지 = The Korean journal of food and nutrition, 22(2): 199~204     
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    12. Shon, Dong-Hwa ; Kim, Mi-Hye ; Kim, Young-Chan ; Kim, Sung-Soo 2010. "Effect of Korean Red Ginseng on the Stability of the Tight Junction of Intestinal Epithelial Cells" 한국식품과학회지 = Korean journal of food science and technology, 42(3): 335~342     
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    16. Jung, Young-Mi ; Ku, Sae-Kwang ; Lee, Dong Sub ; Kwon, Kisang 2016. "Mouse Single Oral Dose Toxicity Test of Lactobacillus-fermented Araliae Continentalis Radix Aqueous Extracts (fACR)" 생명과학회지 = Journal of life science, 26(2): 204~211     

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