본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

The Korean journal of parasitology v.42 no.4 = no.132, 2004년, pp.159 - 167  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Codon usage and bias in mitochondrial genomes of parasitic platyhelminthes

Le, Thanh-Hoa    (Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research and The University of Queensland, Institute of Biotechnolog(IBT)   ); Mcmanus, Donald-Peter    (Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research and The University of Queensland   ); Blair, David    (School of Tropical Biology, James Cook University  );
  • 초록

    Sequences of the complete protein-coding portions of the mitochondrial (mt) genome were analysed for 6 species of cestodes (including hydatid tapeworms and the pork tapeworm) and 5 species of trematodes (blood flukes and liver- and lung-flukes). A near-complete sequence was also available for an additional trematode (the blood fluke Schistosoma malayensis). All of these parasites belong to a large flatworm taxon named the Neodermata. Considerable variation was found in the base composition of the protein-coding genes among these neodermatans. This variation was reflected in statistically-significant differences in numbers of each inferred amino acid between many pairs of species. Both convergence and divergence in nucleotide, and hence amino acid, composition was noted among groups within the Neodermata. Considerable variation in skew (unequal representation of complementary bases on the same strand) was found among the species studied. A pattern is thus emerging of diversity in the mt genome in neodermatans that may cast light on evolution of mt genomes generally.


  • 주제어

    base composition .   codon usage .   mitochondrial genome organisation .   mitochondrial genomes .   Platyhelminthes .   skew.  

  • 참고문헌 (19)

    1. Douglas SE (1995) DNA Strider. An inexpensive sequence analysis package for the Macintosh. Mol Biotechnol 3: 37-45 
    2. Foster PG, Hickey DA (1999) Compositional bias may affect both DNA-based and protein-based phylogenetic reconstructions. J Mol Evol 48: 284-290 
    3. Le TH, Humair PF, Blair D, Agatsuma T, Littlewood DT, McManus DP (2001) Mitochondrial gene content, arrangement and composition compared in African and Asian schistosomes. Mol Biochem Parasitol 117: 61-71 
    4. Littlewood DTJ, Bray RA (2001) Interrelationships of the Platyhelminthes. Taylor & Francis, London, UK 
    5. Cribb TH, Bray RA, Littlewood DTJ, Pichelin SP, Herniou EA (2001) The Digenea. In Interrelationships of the Platyhelminthes, Littlewood DTJ, Bray RA (eds). pp168-185, Taylor & Francis, London, UK 
    6. von Nickisch-Rosenegk M, Brown WM, Boore JL (2001) Complete sequence of the mitochondrial genome of the tapeworm Hymenolepis diminuta: gene arrangements indicate that platyhelminths are eutrochozoans. Mol Biol Evol 18: 721-730 
    7. Perna NT, Kocher TD (1995) Patterns of nucleotide composition at fourfold degenerate sites of animal mitochondrial genomes. J Mol Evol 41: 353-358 
    8. Saccone C, De Giorgi C, Gissi C, Pesole G, Reyes A (1999) Evolutionary genomics in Metazoa: the mitochondrial DNA as a model system. Gene 238: 195-209 
    9. Le TH, Blair D, Agatsuma T, et al. (2000a) Phylogenies inferred from mitochondrial gene orders ― a cautionary tale from the parasitic flatworms. Mol Biol Evol 17: 1123-1125 
    10. Saccone C, Gissi C, Reyes A, Larizza A, Sbisa E, Pesole G (2002) Mitochondrial DNA in Metazoa: degree of freedom in a frozen event. Gene 286: 3-12 
    11. Strimmer K, von Haeseler A (1996) Quartet puzzling: a quartet maximum likelihood method for reconstructing tree topologies. Mol Biol Evol 13: 964-969 
    12. Telford MJ, Herniou EA, Russell RB, Littlewood DT (2000) Changes in mitochondrial genetic codes as phylogenetic characters: two examples from the flatworms. Proc Natl Acad Sci USA 97: 11359-11364 
    13. Nakao M, Sako Y, Yokoyama N, Fukunaga M, Ito A (2000) Mitochondrial genetic code in cestodes. Mol Biochem Parasitol 111: 415-424 
    14. Wolstenholme DR (1992) Animal mitochondrial DNA, structure and evolution. Int Rev Cytol 141: 173-216 
    15. Le TH, Blair D, McManus DP (2002a) Mitochondrial genomes of parasitic flatworms. Trends Parasitol 18: 206-213 
    16. Le TH, Pearson MS, Blair D, Dai N, Zhang LH, McManus DP (2002b) Complete mitochondrial genomes confirm the distinctiveness of the horse-dog and sheep-dog strains of Echinococcus granulosus. Parasitology 124: 97-112 
    17. Blair D, Le TH, Despres L, McManus D (1999) Mitochondrial genes of Schistosoma mansoni. Parasitology 119: 303-313 
    18. Reyes A, Gissi C, Pesole G, Saccone C (1998) Asymmetrical directional mutation pressure in the mitochondrial genome of mammals. Mol Biol Evol 15: 957-966 
    19. Le TH, Blair D, McManus DP (2000b) Mitochondrial genomes of human helminths and their use as markers in population genetics and phylogeny. Acta Trop 77: 243-256 

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기