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Antidiabetic Coumarin and Cyclitol Compounds from Peucedanum japonicum

Lee, Sung-Ok    (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University   ); Choi, Sang-Zin    (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University   ); Lee, Jong-Hwa    (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University   ); Chung, Sung-Hyun    (Pharmacology Lab, College of Pharmacy, Kyung Hee University   ); Park, Sang-Hyun    (Pharmacology Lab, College of Pharmacy, Kyung Hee University   ); Kang, Hee-Chol    (Natural Products Project, R&D Center of Pharmaceuticals of Science & Technology   ); Yang, Eun-Young    (Natural Products Project, R&D Center of Pharmaceuticals of Science & Technology   ); Cho, Hi-Jae    (Natural Products Project, R&D Center of Pharmaceuticals of Science & Technology   ); Lee , Kang-Ro    (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University  );
  • 초록

    The antidiabetic activity-guided fractionation and isolation of the 80% EtOH extracts from Peucedani Radix (Peucedanum japonicum, Umbelliferae) led to the isolation and characterization of a coumarin and a cyclitol as active principles, that is, peucedanol 7-O- ${\beta}$ -D-glucopyranoside (1) and myo-inositol (2). Their structures were identified by spectroscopic methods. Compound 1 showed 39% inhibition of postprandial hyperglycemia at 5.8 mg/kg dose, and compound 2 also significantly inhibited postprandial hyperglycemia by 34% (P


  • 주제어

    Peucedanum japonicum .   Umbelliferae .   Coumarin .   Inositol.  

  • 참고문헌 (8)

    1. Attels, A. S., Zhou, Y. P., Xie, J. T., Wu, J. A., Zhang, L., and Dey, L., Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes, 51, 1851-1858 (2002) 
    2. Ikeshiro, Y., Mase, I., and Tomita, Y., Coumarin glycosides from Peucedanum japonicum. Phytochemistry, 35, 1339-1341 (1994) 
    3. Loewus, F. A. and Murthy, P P. N., myo-Inositol metabolism in plants. Plant. Sci., 150, 1-19 (2000) 
    4. Trinder, P., Determination of blood glucose using an oxidaseperoxidase system with a non-carcinogenic chromogen. J. Clin. Pathol., 22, 158-161 (1969) 
    5. Bae, K. H., The medicinal plants of Korea. Kyohaksa, Seoul, Korea, p.380, (2001) 
    6. Xie, J. T., Aung, H. H., Wu, J. A., Attele, A. S., and Yuan, C. S., Effects of American ginseng berry extract on blood glucose levels in ob/ob mice. Am. J. Chin Med., 30, 187-194 (2002) 
    7. Chen, I. S., Chang, C. T., Sheen, W S., Teng, C. M., Tsai, I. L., Duh, C. Y., and Ko, F. N., Coumarins and antiplatelet aggregation constituents from formosan Peucedanum japonicum. Phytochemistry, 41, 525-530 (1996) 
    8. Yoo, S. W., Kim, J. S., Kang, S. S., Son K. H., Chang H. W., Kim, H. P., Bae, K. H., and Lee, C. O., Constituents of the fruits and leaves of Euodia daniellii. Arch. Pharm. Res., 25, 824-830 (2002) 
  • 이 논문을 인용한 문헌 (7)

    1. 2007. "" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 15(5): 357~361     
    2. Song, Hong-Seon ; Cho, Woo 2007. "Growth Pattern and Species Composition by Landform and Seaside Distribution of Peucedanum japonicum Thunb. Community Group in Korea" 한국환경생태학회지 = Korean journal of environment and ecology, 21(1): 74~81     
    3. Kim, Do-Hoon ; Han, Chi-Su ; Kim, Gi-Eun ; Kim, Jin-Hyo ; Kim, Sung-Gun ; Kim, Ho-Kyoung ; Oh, O-Jin ; Whang, Wan-Kyunn 2009. "Biolosical Activities of Isolated Compounds from Peucedani Radix" 약학회지 = Yakhak hoeji, 53(3): 130~137     
    4. Jin, Yong-Xie ; Cho, Young-Sook ; Choi, Youngmin 2014. "Nutritional quality of Peucedanum japonicum Thunb. leaves in relation to ripening time, growing condition and blanching" 한국식품저장유통학회지 = Korean journal of food preservation, 21(6): 784~789     
    5. Jung, Ho-Kyung ; Jung, Won-Seok ; Ahn, Byung-Kwan ; Kang, Byoung-Man ; Yeo, Jun-Hwan ; Cha, Seon-Woo ; Park, Chun-Geon ; Cho, Jung-Hee ; Cho, Hyun-Woo 2014. "Peucedanum japonicum Thunberg Leaf Alleviates the Symptoms of Dextran Sulfate Sodium Induced Ulcerative Colitis in Mice" 韓國資源植物學會誌 = Korean journal of plant resources, 27(5): 421~428     
    6. Song, Ki Seon ; Jeon, Kwon Seok ; Yoon, Jun Hyuck ; Kim, Chang Hwan ; Park, Yong Bae ; Kim, Jong Jin 2014. "Characteristics of Growth and Root Development of Peucedanum japonicum Seedling by Shading Rate and Container Size" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 22(5): 384~390     
    7. Song, Ki Seon ; Jeon, Kwon Seok ; Choi, Kyu Seong ; Kim, Chang Hwan ; Park, Yong Bae ; Kim, Jong Jin 2015. "Characteristics of Photosynthesis and Leaf Growth of Peucedanum japonicum by Leaf Mold and Shading Level in Forest Farming" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 23(1): 43~48     

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