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Suppressive Effects of Platycodon grandiflorum on the Progress of Carbon Tetrachloride-Induced Hepatic Fibrosis

Lee, Kyung-Jin    (Department of Pharmacy, College of Pharmacy   ); Kim, Ji-Young    (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials Chosun University   ); Jung, Kyung-Sik    (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials Chosun University   ); Choi, Chul-Yung    (Division of Food Science, Chinju International University   ); Chung, Young-Chul    (Division of Food Science, Chinju International University   ); Kim, Dong-Hee    (Department of Pathology, College of Oriental Medicine, Daejeon University   ); Jeong , Hye-Gwang    (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials Chosun University  );
  • 초록

    The suppressive effects of Platycodi Radix (Changkil: CK), the root of Platycodon grandiflorum A. DC (Campanulaceae), on the progress of acute carbon tetrachloride $(CCl_4)$ -induced hepatic fibrosis were investigated in the rat. CK significantly suppressed $(CCl_4)$ -induced hepatic necrosis and inflammation, as determined by the serum enzymatic activities of alanine and aspartate aminotransferase and serum tumor necrosis factor- ${\alpha}$ levels, in dose-dependent manners. In addition, the increased hepatic fibrosis after acute $(CCl_4)$ treatment was suppressed by the administration of CK. CK also significantly prevented the elevation of hepatic ${\alpha}$ 1(I) procollagen (type I collagen) mRNA and ${\alpha}$ -smooth muscle actin ( ${\alpha}$ -SMA) expressions in the liver of $(CCl_4)$ -intoxicated rats and also suppressed the induction of ${\alpha}$ -SMA and type I collagen in cultured hepatic stellate cells, in dose-dependent manners. These results suggest that the suppressive effects of CK against the progress of acute $(CCl_4)$ -induced hepatic fibrosis possibly involve mechanisms related to its ability to block both hepatic inflammation and the activation of hepatic stellate cells.

  • 주제어

    Platycodi Radix .   Carbon tetrachloride .   Hepatic fibrosis .   Hepatic stellate cells.  

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  • 이 논문을 인용한 문헌 (2)

    1. Won, Hyang Rye 2013. "The Hypocholesterolemic Effect of Platycodi radix Saponin in Rats Fed a Hypercholesterol Diet" 한국지역사회생활과학회지 = The Korean Journal of Community Living Science, 24(1): 141~149     
    2. 2015. "" Korean journal of crop science = 韓國作物學會誌, 60(2): 239~247     

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