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한국수산학회지 = Journal of the Korean Fisheries Society v.37 no.3, 2004년, pp.192 - 196   피인용횟수: 3

Bisphenol A가 점 망둑 (Chasmichthys dolichognothus)의 난소 스테로이드 호르몬 대사에 미치는 영향
Effect of Bisphenol A on Ovarian Steroidogenesis in Longchin Goby (Chasmichthys dolichognathus)

백혜자   (부경대학교 자원생물학과UU0000598  ); 박명희   (부경대학교 자원생물학과UU0000598  ); 이영돈   (제주대학교 해양과환경연구소UU0001165  ); 김형배   (강원도립대학 해양생물자원개발과UU0001580  ); 김재원   (부경대학교 자원생물학과UU0000598  ); 유명숙   (부경대학교 자원생물학과UU0000598  );
  • 초록

    The in vitro effect of bisphenol A (BPA) on ovarian steroidogenesis of the longchin goby (Chasmichthys dolichognathus) was investigated. Oocytes taken during the maturing phase (vitellogenic, fully vitellogenic or germinal vesicle breakdown stage) were incubated with BPA (100 ng/mL) in the presence of exogenous precursor $^{3}H-17\alpha\;hydroxyprogesterone\;(^{3}H-17\alphaOHP).$ Steroids were extracted from the media and the isolated oocytes, and the extracts were separated and identified by thin layer chromatography and gas chromatography-mass spectrometry. The identities of the major metabolites were progestogens $[17{\alpha}-hydroxy,20{\alpha}-dihydroprogesterone\;(17{\alpha}20{\alpha}OHP)\;and\;17{\alpha}-hydrxy,20{\beta}-dihydroprogesterone\;(17{\alpha}20{\beta}OHP),$ androgens [androstenedione (A4) and testosterone (T)] and estrogens [estrone $(E_1)\;and\;estradiol-17{\beta}(E_2)].$ BPA treatment inhibited production of estrogens in all the maturing phases and progestogens in the germinal vesicle migrating stage. Percentage yield of estrogens was decreased with increased yield of androgens. In conclusion, BPA had an inhibitory effect on the conversion of $^3H-17\alphaOHP$ to estrogens and progestogens. These results demonstrate that BPA can act either estrogenic or anti-estrogenic effects.


  • 주제어

    Bisphenol A .   Chasmichthys dolichognathus .   Vitellogenesis .   Estrogenic activity .   GVBD .   Estrogen .   Progestogen.  

  • 참고문헌 (23)

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  • 이 논문을 인용한 문헌 (3)

    1. 2013. "" Development & reproduction = 발생과 생식, 17(4): 353~361     
    2. 2013. "" Development & reproduction = 발생과 생식, 17(4): 353~361     
    3. Cho, Gab Ja ; Kim, Hyeon Ji ; Park, Jong Hyeok ; Choi, Hee Chan ; Baeck, Gun Wook 2016. "Feeding habits of longchin goby, Chaenogobius annularis in the tidepools at the intertidal zone of Tongyeong, Korea" Korean journal of Ichthyology = 한국어류학회지, 28(4): 267~272     

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