본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

이소플라본을 투여한 난소절제 흰쥐 대퇴골의 생체역학적 분석
The Biomechanical Characteristics of Isoflavone-Treated Ovariectomized Rat's Femur

강석원   (National Institute of Agricultural Engineering, RDACC0187572  ); 박유헌   (Institute of Life Science & Natural Resources, Korea UniversityUU0000159  ); 백민경   (Department of Food and Nutrition, Hanyang UniversityUU0001519  ); 엄애선   (Department of Food and Nutrition, Hanyang UniversityUU0001519  );
  • 초록

    This study was to investigate the biomechanical characteristics of isoflavone-treated ovariectomized growing rat's femur. 4-week-old Wistar (female rats were randomly divided into 5 groups and assigned to sham(SH) group, and four ovariectomized groups consisting of one ovariectomized(OVX) group and genisetin(10 mg/kg b.w. )(OVX+G), daidzein(10 mg/kg b.w.)(OVX+D), and 17 $\beta$ -estradiol(10 $\mu$ g/kg b.w.)(OVX+ES) in AIN-76 modified diet for 8 weeks. The OVX groups gained more body weight than the SH group. Femoral weight was increased by feeding genistein and estradiol, whereas femoral length among groups was not significantly different. The breaking farce, stiffness, deformation, and energy values of the OVX group were lower than those of other groups. The stress, strain, and Young's modulus values of the OVX group were higher than those of other groups.


  • 주제어

    Biomechanics .   Isoflavone .   Femur .   Ovariectomized rat.  

  • 참고문헌 (14)

    1. Duncan, D. B. 1957. Multiple Range Tests for correlated and heteroscedastic Means. Biometrics. 13(2):164-176 
    2. Kalu, D. N. 1991. The ovariectomized rat model of postmenopausal bone loss. Bone Mineral. 15(3): 175-191 
    3. Miksicek, R. J. 1995. Estrogenic flavonoids: structural requirements for biological activity. Proceedings of the Society for Experimental Biology and Medicine. 208(1):44-50 
    4. Pastoureau P., A. Chomel and J. Bonnet. 1995. Specific evaluation of localized bone mass and bone loss in the rat using dual-energy X-ray absorptiometry subregional analysis. Osteoporosis International 5(3):143-149 
    5. Reeves, P. G., F. H. Nielsen and G. C. Fahey Jr. 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. Journal of Nutrition. 123(11):1939-1951 
    6. Turner, C. H. and D. B. Burr. 1993. Basic biomechanical measurements of bone: A tutorial. Bone. 14(4):595-608 
    7. Grodin, J. M., P. K. Siiteri and P. C. MacDonald. 1973. Source of estrogen production in postmenopausal women. Journal of Clinical Endocrinology and Metabolism. 36(2):207-214 
    8. Felson D. T., Y. Zhang, M. T. Hannan, D. P. Kiel, P. W. Wilson and J. J. Anderson. 1993. The effect of postmenopausal estrogen therapy on bone density in elderly women. New England Journal of Medicine. 329(16): 1141-1146 
    9. 박명희, 윤 선, 정수연, 양승오, 유태무, 양지선, 권대중. 2001. 이소플라본 보충이 난소절제 흰쥐의 골대사에 미치는 영향. 한국식품영양과학회지. 30(4):657-661 
    10. Gurkan, L., A. Ekeland, K. M. Gautvik, N. Langeland, H. Ronningen and L. F. Solheim. 1986. Bone changes after castration in rats. Acta Orthopaedica Scandinavica. 57(1):67-70 
    11. Arjmandi, B. H., R. S. Birnbaum, S. Juma, E. Barengolts and S. C. Kukreja. 2000. The synthetic phytoestrogen, ipriflavone, and estrogen prevent bone loss by different mechanisms. Calcified Tissue International. 66(1):61-65 
    12. Thomas, M. L., M. J. Ibarra, B. Solcher, S. Wetzel and D. J. Simmons. 1988. The effect of low dietary calcium and calcium supplementation on calcium metabolism and bone in the immature, growing rat. Bone Mineral. 4(1):73-82 
    13. Adlercreutz, H. 1990. Western diet and western diseases; some hormonal and biochemical mechanisms and associations. Scandinavian Journal of Clinical and Laboratory Investigation. 50(S201);3-23 
    14. St. Clair, R. W. 1998. Estrogens and atherosclerosis: phytoestrogens and selective estrogen receptor modulators. Current Opinion in Lipidology 9(5):457-463 

 저자의 다른 논문

  • 박유헌 (1)

    1. 2007 "Effect of Dietary Inclusion of Lactobacillus acidophilus ATCC 43121 on Cholesterol Metabolism in Rats" Journal of microbiology and biotechnology 17 (4): 655~662    
  • 엄애선 (48)

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • NDSL :
  • 한국농업기계학회 : 저널
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기