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Rosin Microparticles as Drug Carriers: Influence of Various Solvents on the Formation of Particles and Sustained-release of Indomethacin

Lee Chang Moon    (Interdisciplinary Program of Biomedical Engineering, Chonnam National University   ); Lim Seung    (Ecobio Inc., Business Incubation Center, Chonnam National University   ); Kim Gwang Yun    (Ecobio Inc., Business Incubation Center, Chonnam National University   ); Kim Do Man    (School of biological Sciences and Technology and Research Institute for Catalysis, Chonnam National University   ); Kim Dong Woon    (Department of Health and Hygiene, Gwang-Yang Health College   ); Lee Hyun Chul    (Department of Microbiology, Chonnam National University Medical School   ); Lee Ki Young    (Department of Applied Chemical Engineering & The Research Institute for Catalysis, Chonnam National University  );
  • 초록

    The aim of this study was to formulate a sustained release system for indomethacin (IND) with rosin gum obtained from a pine tree. Rosin microparticles were prepared by a disper­sion and dialysis method without the addition of surfactant. In order to investigate the influence of solvents on the formation of colloidal microparitcles, various solvents like ethanol, DMF, DMAc, and acetone were used. The rosin microparticles containing IND were characterized by X­ray differactometry (XRD) and differential scanning calorimetry (DSC). The morphologies of rosin microparticles observed by scanning electron microscopy (SEM) were spherical. The solvents used to dissolve rosin significantly affected the drug content and drug release rate of IND. The release behaviors of IND from the rosin microparticles were dependent on the drug content and size of the particles. Rosin micorparticles with a higher drug content and of a larger particle size had a slower drug release rate. Also, the IND release rate from the rosin microparticles could be regulated by the rosin content in the microparticles. From these results, rosin microparticles have the potential of being used as a sustained release system of IND.


  • 주제어

    rosin gum .   indomethacin .   sustained release .   microparticle.  

  • 참고문헌 (23)

    1. Ramani, C. C., P. K. Puranik, and A. K. Dorle (1996) Study of diabietic acid as matrix forming material. Int. J. Pharm. 137: 11-19 
    2. Yeo, Y., N. J. Baek, and K. N. Park (2001) Microencapsulation methods for delivery of protein drugs. Biotechnol. Bioprocess Eng. 6: 213-230 
    3. Jung, S. W., Y. I. Jeong, and S. H. Kim (2003) Charac-terization of hydrophobized pullulan with various hydro-phobicities. Int. J. Pharm. 254: 109-121 
    4. Wilhelm, M., C. L. Zhao, Y. Wang, R. Xu, M. A. Winnik, J. L. Mura, G. Riess, and M. D. Croucher (1991) Poly (styrene-ethylene oxide) block copolymer micelle formation in water: A fluorescence probe study. Macromolecules 24: 1033-1040 
    5. Jeong, Y. I., J. B. Cheon, S. H. Kim, J. W. Nah, Y. M. Lee, Y. K. Sung, T. Akaite, and C. S. Cho (1998) Clonazepam release from core-shell type microparticles in vitro. J. Control. Release 51: 169-178 
    6. Kown, G. S., M. Naito, M. Yokoyama, T. Okano, Y. Sakurai, and K. Kataoka (1995) Physical entrapment of adriamycin in AB block copolymer micelles. Pharm. Res. 12: 192-195 
    7. Mandaogade, P. M., P. M. Satturwar, S. V. Fulzele, B. B. Gogte, and A. K. Dorle (2002) Rosin derivatives: Novel film forming materials for controlled drug delivery. Reactive Func. Polymers 50: 233-242 
    8. Fulzele, S. V., P. M. Satturwar, and A. K. Dorle (2002) Polymerized rosin: Novel film forming polymer for drug delivery. Int. J. Pharm. 249: 175-84 
    9. Eis, M. J., B. M. Watkins, A. Philip, and R. E. Welling (1998) Non-steroidal-induced benign structures of colon: A case report and review of the literature. Am. J. Gastroenterol. 93: 120-121 
    10. Kim, S. Y., I. G. Shin, and Y. M. Lee (1999) Amphiphilic diblock copolymeric nanospheres composed of methoxy poly(ethylene glycol) and glycolide: Properties, cytotoxicity and drug release behavior. Biomaterials 20: 1033-1042 
    11. La, S. B., T. Okano, and K. Kataoka (1996) Preparation and characterization of the micelle-forming polymeric drug indomethacin-incorporated poly(ethylene oxide)-poly ( -benzyl L-aspartate) block copolymer micelles. J. Pharm. Sci. 85: 85-90 
    12. Joseph, I. and S. Venkatoran (1995) Indomethacin sustained release from alginate-gelatin or pectin-gelatin coacervates. Int. J. Pharm. 126: 161-168 
    13. Jeon, H. J., Y. I. Jeong, M. K. Jang, Y. H. Park, and J. W. Nah (2000) Effect of solvent on the preparation of surfactant-free poly(DL-lactide-co-glycolide) nano-particles and norfloxacin release characteristics. Int. J. Pharm. 207: 99-108 
    14. Gref, R., Y. Minamitake, M. T. Peracchia, V. Trubetskoy, V. Torchilin, and R. Langer (1994) Biodegradable long-cir-culating polymeric nanospheres. Science 263: 1600-1603 
    15. Uzunkaya, G. and N. Bergisadi (2003) In vitro drug liberation and kinetics of sustained release indomethacin suppository. Il Farmaco 58: 509-512 
    16. Khanfar, M. S., N. M. Najib, and G. K. Pillai (1997) Dissolution behaviour of sustained release formulation of indomethacin with Eudragit RS. Acta Pharm. Hung. 67: 235-239 
    17. Puranik, P. K. and A. K. Dorle (1991) Study of a abietic acid-glycerol derivatives as microencapsulating materials. J. Microencapsulation 8: 247-252 
    18. Kam, S. H., E. S. Park, and S. C. Chi (1995) Skin Permeation of indomethacin from Gels. J. Kor. Pharm. Sci. 25: 129-136 
    19. Fulzele, S. V., P. M. Satturwar, and A. K. Dorle (2003) Study of the biodegradation and in vivo biocompatibility of novel biomaterials. Eur. J. Pharm. Sci. 20: 53-61 
    20. Lee, C. M., D. W. Kim, H. C. Lee, and K. Y. Lee, (2004) Pectin microspheres for oral colon delivery: Preparation using spray drying method and in vitro release of indomethacin. Biotechnol. Bioprocess Eng. 9: 191-195     
    21. Flower, R. J. (1994) Drugs which inhibit prostaglandin biosynthesis. Pharm. Rev. 26: 33-67 
    22. Karasulu, E., H. Y. Karasulu, G. Ertan, L. Kirilmaz, and T. Guneri (2003) Extended release lipophilic indomethacin microspheres: Formulation factors and mathematical equations fitted drug release rates. Eur. J. Pharm. Sci. 19: 9-104 
    23. Na, K., Y. E. Kim, and K. Y. Lee, (1999) Preparation of microparticles in drug delivery system using guar derivatives and dialysis method. J. Microbiol. Biotechnol. 9: 50-55 

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