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Journal of microbiology and biotechnology v.14 no.6, 2004년, pp.1163 - 1169   피인용횟수: 2
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Model Development for Lactic Acid Fermentation and Parameter Optimization Using Genetic Algorithm

LIN , JIAN-QIANG    (State Key Lab of Microbial Technology, School of Life Science, Shandong University   ); LEE, SANG-MOK   (Department of Biological Engineering, ERC for Advanced Bioseparation Technology, Inha UniversityUU0001092  ); KOO, YOON-MO   (Department of Biological Engineering, ERC for Advanced Bioseparation Technology, Inha UniversityUU0001092  );
  • 초록

    An unstructured mathematical model is presented for lactic acid fermentation based on the energy balance. The proposed model reflects the energy metabolic state and then predicts the cell growth, lactic acid production, and glucose consumption rates by relating the above rates with the energy metabolic rate. Fermentation experiments were conducted under various initial lactic acid concentrations of 0, 30, 50, 70, and 90 g/l. Also, a genetic algorithm was used for further optimization of the model parameters and included the operations of coding, initialization, hybridization, mutation, decoding, fitness calculation, selection, and reproduction exerted on individuals (or chromosomes) in a population. The simulation results showed a good fit between the model prediction and the experimental data. The genetic algorithm proved to be useful for model parameter optimization, suggesting wider applications in the field of biological engineering.


  • 주제어

    Model .   lactic acid .   fermentation .   genetic algorithm .   optimization.  

  • 참고문헌 (12)

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    3. Lin, J. Q., S. M. Lee, H. J. Lee, and Y. M. Koo. 2000. Modeling of typical microbial cell growth in batch culture. Biotechnol. Bioprocess Eng. 5: 382-385 
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    5. Vickroy, T. B. 1985. Lactic acid, pp. 761-776. In: Blanch, H. W., Drew, S. and Wang, D. I. C. (eds.), The Practice of Biotechnology: Commodity Products. Pergamon Press, Elmsford, NY, U.S.A 
    6. Suh, I. S. and S. B. Lee. 2003. Optimization of radiator position in an internally radiating photobioreactor: a model simulation study. J. Microbiol. Biotechnol. 13(5): 789-793 
    7. Luedeking, R. and E. L. Piret. 1959. A kinetic study of the lactic acid fermentation. J. Biochem. Microbiol. 1: 393-412 
    8. Boonmee, M., N. Leksawasdi, W. Bridge, and P. L. Rogers. 2003. Batch and continuous culture of Lactococcus lactis NZ133: Experimental data and model development. Biochem. Eng. J. 14: 127-135 
    9. Goldberg, D. E. 1989. Genetic Algorithm in Search, Optimization and Machine Learning. Addison Wesley, U.S.A 
    10. Olmos-Dichara, A., F. Ampe, J. Uribelarrea, A. Pareilleux, and G. Goma. 1997. Growth and lactic acid production by Lactobacillus casei ssp. Rhamnosus in batch and membrane bioreactor. Biotechnol. Lett. 8: 709-714 
    11. Kim, N.-J., I. S. Suh, B.-K. Hur, and C.-G. Lee. 2002. Simple monodimensional model for linear growth rate of photosynthetic microorganisms in flat-plate photobioreactors. J. Microbiol. Biotechnol. 12(6): 962-972 
    12. Nielsen, J., K. Nikolajsen, and J. Villadsen. 1991. Structured modeling of a microbial system, part 1, 2. Biotechnol. Bioeng. 38: 1-10, 11-23 
  • 이 논문을 인용한 문헌 (2)

    1. 2006. "" Journal of microbiology and biotechnology, 16(6): 863~869     
    2. 2006. "" Journal of microbiology and biotechnology, 16(9): 1355~1361     

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