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Journal of microbiology and biotechnology v.14 no.6, 2004년, pp.1338 - 1342   피인용횟수: 1
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Cyclosophoraose as a Novel Chiral Stationary Phase for Enantioseparation

JUNG, YUN-JUNG    (Department of Microbial Engineering and Bio/Molecular Informatics Center, Konkuk University   ); LEE, SANG-HOO    (Department of Microbial Engineering and Bio/Molecular Informatics Center, Konkuk University   ); PAIK, SEUNG-R.    (School of Chemical Engineering, Seoul National University   ); JUNG, SEUN-HO    (Department of Microbial Engineering and Bio/Molecular Informatics Center, Konkuk University  );
  • 초록

    Cyclosophoraoses (Cys), cyclic ${\beta}-(1{\rightarrow}2)-D-glucans$ produced by Rhizobium meliloti 2011, were used as a novel chiral stationary phase for the enantiomeric separation. A novel Cys stationary phase, chemically immobilized onto porous silica via aminopropyltrimethoxysilane as a molecular linker, showed good separation for each racemate of bupivacain (separation factor, $\alpha$ =1.3), p 1.3), propranolol ( $\alpha$ =1.3), a 1.3), and fenoprofen ( $\alpha$ =2.9), r 2.9), respectively, under the mobile phase of water: methanol (80:20, v/v) at a constant flow rate of 0.9 ml/min at pH7.


  • 주제어

    Chiral separation .   cyclosophoraoses .   HPLC .   chiral stationary phases.  

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  • 이 논문을 인용한 문헌 (1)

    1. 2009. "" BMB reports, 42(12): 769~775     

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