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The journal of microbiology v.42 no.4, 2004년, pp.336 - 339  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Hydrogen Peroxide produced by Two Amino Acid Oxidases Mediates Antibacterial Actions

Zhang Hongmin    (Key Laboratory of Structural Biology, Chinese Academy of Sciences   ); Yang Qiuyue    (Hefei National Laboratory for Physical Sciences at Microscale   ); Sun Mingxuan    (Department of Molecular and Cell Biology, School of Life Sciences, University of Science and Technology of China   ); Teng Maikun    (Department of Molecular and Cell Biology, School of Life Sciences, University of Science and Technology of China ;  ); Niu Liwen  
  • 초록

    The antibacterial actions of two amino acid oxidases, a D-amino acid oxidase from hog kidney and a L-amino acid oxidase from the venom of Agkistrodon halys, were investigated, demonstrating that both enzymes were able to inhibit the growth of both Gram-positive and Gram-negative bacteria, and that hydrogen peroxide, a product of their enzymatic reactions, was the antibacterial factor. However, hydrogen peroxide generated in the enzymatic reactions was not sufficient to explain the degree to which bacterial growth was inhibited. A fluorescence labeling assay showed that both of these two enzymes could bind to the surfaces of bacteria. To the best of our knowledge, this is the first report regarding the antibacterial activity of the D-amino acid oxidases.


  • 주제어

    amino acid oxidase .   antibacterial activity .   snake venom.  

  • 참고문헌 (14)

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