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Sesquiterpenes from Syneilesis palmata and Their Cytotoxicity Against Human Cancer Cell Lines In Vitro

Lee Kyu Ha    (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University   ); Cho Sang Un    (Research Institute of Chemical Technology   ); Lee Kang Ro    (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University  );
  • 초록

    The chromatographic separation of the MeOH extract from the aerial parts of Syneilesis palmata led to the isolation of a new sesquiterpene glycoside 4, together with four known compounds. Their structures were characterized to be 4 $\beta$ ,5 $\beta$ -epoxy-caryophill-8,(15)-ene (1), 3 $\beta$ ­hydroxy-gultin-5-ene (2), 4 $\alpha$ ,5 $\beta$ -dihydroxy-caryophill-8,(15)-ene (3), (-)-oplopan-4-one-10- $\alpha$ -O­ $\beta$ -D-glucose (4) and 3-hexenyl-1-O- $\beta$ -D-glucopyranose (5), based on spectroscopic and chemical methods. Compound 2 showed moderate cytotoxicity against five human tumor cell lines in vitro with its EDso values ranging from 5.90-1 0.83 $\mu$ g/mL.


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  • 이 논문을 인용한 문헌 (5)

    1. 2007. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 30(9): 1067~1074     
    2. 2008. "" Natural product sciences, 14(2): 100~106     
    3. 2009. "" Natural product sciences, 15(1): 44~49     
    4. Lee, Yang-Suk ; Seo, Soo-Jung ; Kim, Nam-Woo 2009. "Analysis of the General Components of Syneilesis palmata Maxim" 한국식품저장유통학회지 = Korean journal of food preservation, 16(3): 412~418     
    5. Lee, Yang-Suk ; Kim, Nam-Woo 2014. "Antioxidant activities of hot water extract of Syneilesis palmata root and aerial part" 한국식품저장유통학회지 = Korean journal of food preservation, 21(1): 9~16     

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