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New Cytotoxic Sulfated Saponins from the Starfish Certonardoa semiregularis

Wang Wei Hong    (College of Pharmacy, Pusan National University   ); Jang Hyo Jin    (College of Pharmacy, Pusan National University   ); Hong Jong Ki    (Basic Science Institute   ); Lee Chong Ok    (Korea Research Institute of Chemical Technology   ); Bae Song Ja    (Silla University   ); Shin Sook    (Sahmyook University   ); Jung Jee H.    (College of Pharmacy, Pusan National University  );
  • 초록

    Two new sulfated saponins designated as certonardosides P $_{2}$ and I $_{3}$ (1 and 2) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis. Compounds 1 and 2 were tested for cytotoxicity against five human tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15), and compound 1 displayed significant cytotoxicity against the SK-MEL-2 skin cancer cell.


  • 참고문헌 (16)

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