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Cytotoxic Constituents of the Octocoral Dendronephthya gigantea

Han Ah Reum    (College of Pharmacy, Ewha Womans University   ); Song Jun Im    (College of Natural Science, Ewha Womens University   ); Jang Dae Sik    (Department of Herbal Parmaceutical Development, Korea Institute of Oriental Medicine   ); Min Hye Young    (College of Pharmacy, Ewha Womans University   ); Lee Sang Kook    (College of Pharmacy, Ewha Womans University   ); Seo Eun Kyoung    (College of Pharmacy, Ewha Womans University  );
  • 초록

    A known monoalkyl glycerol ether, ( $\pm$ )-1-nonadecyloxy-2,3-propanediol (1) was isolated from the ethyl acetate extract of a soft coral Dendronephthya gigantea as a weakly cytotoxic constituent against four human cancer cell lines, A549, HT-29, HT-1080, and SNU-638. In addition, a known ceramide, (28,3R,4E,8E)-N-hexadecanoyl-2-amino-4,8-octadecadiene-1 ,3-diol (2), was also isolated as an inactive constituent. This is the first report on the isolation of the compounds 1 and 2 from the octocoral, Dendronephthya species.


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