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Potentially Bioactive Two New Natural Sesquiterpenoids from the Rhizomes of Zingiber zerumbet

Jang Dae Sik    (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine   ); Seol Eun Kyoung    (College of Pharmacy, Ewha Womans University  );
  • 초록

    Repeated chromatography of the n-hexane-soluble fraction of the MeOH extract of the rhizomes of Zingiber zerumbet led to the isolation of two isomers of 6-methoxy-2E,9E-humula-dien-8-one (1 and 2) and stigmast-4-en-3-one. The structures of 1 and 2 were determined by spectroscopic methods including 10 and 2D-NMR elucidated by analysis of spectroscopic data as well as by comparison with published values. This is the first report on the isolation of compounds 1 and 2 from the nature. Stigmast-4-en-3-one was first isolated from this plant.


  • 참고문헌 (12)

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    2. Matthes, H. W. D., Luu, B., and Ourisson, G., Chemistry and Biochemistry of Chinese drugs. Part VI. Cytotoxic components of Zingiber zerumbet, Curcuma zedoaria and C. domestica. Phytochemistry, 19, 2643-2650 (1980) 
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    11. Kitayama, T., Okamoto, T., Hill, R. K., Kawai, Y., Takahashi, S., Yonemori, S., Yamamoto Y., Ohe, K., Uemura, S., and Sawada, S., Chemistry of zerumbone. 1. Simplified isolation, conjugate addition reactions, and a unique ring contracting transannular reaction of its dibromide. J. Org. Chem., 64, 2667-2672 (1999) 
    12. Tanaka, T., Shimizu, M., Kohno, H., Yoshitani, S. -I., Tsukio, Y., Murakami, A., Safitri, R., Takahashi, D., Yamamoto, K., Koshimizu, K., Ohigashi, H., and Mori, H., Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet. Life Sci., 69, 1935-1945 (2001) 

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