본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Journal of microbiology and biotechnology v.15 no.2, 2005년, pp.384 - 387   피인용횟수: 1

Structures and Biological Activities of Novel Antibiotic Peptaibols Neoatroviridins A-D from Trichoderma atroviride F80317

OH SEUNG UK    (Korea Research Institute of Bioscience and Biotechnology   ); YUN BONG SIK    (Korea Research Institute of Bioscience and Biotechnology   ); LEE SANG JUN    (Pharmaceutical and Health Research Institute, Pacific Corporation   ); YOO ICK DONG    (Korea Research Institute of Bioscience and Biotechnology  );
  • 초록

    Four new antibiotic peptaibols, named neoatroviridins A (1), B (2), C (3), and D (4), have been isolated from the culture broth of Trichoderma atroviride. Their amino acid sequences were determined mainly by mass spectrometry in combination with NMR studies. The absolute stereochemistry of neoatroviridins was established as L by GC analysis of their acid hydrolysates with derivatization, except for isovaline which was in D. Neoatroviridins, composed of 18 amino acid residues, showed significant membrane-perturbing activity responsible for their antibiotic action, which was comparable to that of alamethicin, a well-known 20-residue peptaibol.


  • 참고문헌 (17)

    1. Fujita, J., S. Wada. A. Ida. T. Nishimura, M. Kanai, and N. Toyama. 1994. Isolation and structural elucidation of new peptaibols, trichodecenins-I and II, from Trichoderma viride. Chem. Pharm. Bull. 42: 489- 494 
    2. Pandey, R. C, J. C. Cook, and K. L. Rinehart. 1977. High resolution and field desorption mass spectrometry studies and revised structures of alamethicins I and II. J. Am. Chem. Soc. 99: 8469- 8483 
    3. Sansom, M. S. P. 1993. Structure and function of channelforming peptaibols. Quart. Rev. Biophys. 26: 365- 421 
    4. Weinstein, J. N., S. Yoshikami, P. Henkart, R. Blumenthal, and W. A. Hagins. 1977. Liposorne-cell interaction: Transfer and intracellular release of a trapped fluorescent marker. Science 195: 489- 491 
    5. Rebuffat, S., S. Hlimi, Y. Prigent. C. Goulard, and B. Bodo. 1996. Isolation and structural elucidation of the 11-residue peptaibol antibiotic, harzianin HK VI. J. Chem. Soc. Perkin Trans 1 2021-2027 
    6. Pandey, R. C., J. C. Cook, and K. L. Rinehart. 1977. Structures of the peptide antibiotics emerimicins III and IV. J. Am. Chem. Soc. 99: 5205- 5206 
    7. Karle, I. L., J. L. Flippen-Anderson, S. Agarwalla, and P. Balaram. 1991. Crystal structure of $[Leu^1]$ zervarmicin, a membrane ion-channel peptide: Implications for gating mechanisms. Proc. Natl. Acad. Sci. USA 88: 5307-5311. 
    8. Mohr, H. and H. Kleinkauf. 1978. Alamethicin biosynthesis: Acetylation of the amino terminus and attachment of phcnylalaninol. Biochim. Biophys. Acta 526: 375- 386 
    9. Lee, H. J., K. W. Lee, K. H. Kim, H. K. Kim, and H. J. Lee. 2004. Antitumor activity of peptide fraction from traditional Korean soy sauce. J. Microbiol. Biotechnol. 14: 628- 630 
    10. Dornberger, K., W. Ihn, M. Ritzau, U. Grafe, B. Schlegel, W. Fleck, and J. W. Metzger. 1995. Chrysosperrnins, new peptaibol antibiotics from Apiocrea chrysosperma AP 101. J. Antibiotics 48: 977- 989 
    11. Ei Hajji, M., S. Rebuffat, T. Le Doan, G. Klein, M. Satre, and B. Bodo. 1989. Interaction of trichorzianines A and B with model membranes and with the amoeba Dictvostelium. Biochim. Biophys. Acta 978: 97- 104 
    12. Kim, M., C. Shin, H. Yang, S. Kim, H. Lim, C. H. Lee, M. Kim, and Y. Lim. 2004. Naltriben analogues as peptide anticancer drugs. J. Microbiol. Biotechnol. 14: 881- 884 
    13. Oh, S.-U., S.-J. Lee, J.-H. Kim, and I.-D. Yoo. 2000. Structural elucidation of new antibiotic peptides, atroviridins A, B and C from Trichoderma atroviride. Tetrahedron Lett. 41:61-64 
    14. Kim, Y. H., W. -H. Yeo, Y. S. Kim, S. Y. Chae, and K. S. Kim. 2000. Antiviral activity of antibiotic peptaibols, chrysospermins Band D, produced by Apioerea sp, 14T against TMV infection. J. Microbiol. Biotechnol. 10: 522-528 
    15. Oh, S.-U., B.-S. Yun, S.-J. Lee, J.-H. Kim, and I.-D. Yoo. 2002. Atroviridins A-C and neoatroviridins A-D, novel peptaibol antibiotics produced by Trichoderma atroviride F80317. I. Taxonomy, fermentation, isolation and biological activity. J. Antibiotics 55: 557 - 564 
    16. Rebuffat, S., M. Ei Hajji, P. Hennig, D. Davoust, and B. Bodo. 1989. Isolation, sequence, and conformation of seven trichorzianines B from Trichoderma harzianum. Int. J. Peptide Protein Res. 34: 200- 210 
    17. Goulard, C., S. Hlimi, and S. Rebuffat. 1995. Trichorzins HA and MA, antibiotic peptides from Trichoderma harzianum. J. Antibiotics 48: 1248- 1253 
  • 이 논문을 인용한 문헌 (1)

    1. 2006. "" Journal of microbiology and biotechnology, 16(6): 880~888     

 저자의 다른 논문

  • Yoo, Ick-Dong (27)

    1. 1995 "Transport of Sulfanilic Acid via Microbial Dipeptide Transport System" Journal of microbiology and biotechnology 5 (6): 315~318    
    2. 1995 "Phenylalanyl-2-Sulfanilylglycine as Substrate for Leucine Aminopeptidase Assay" Journal of microbiology and biotechnology 5 (6): 319~323    
    3. 1996 "A Sesquiterpene ortho-Naphthoquinone from the Root Bark of Ulmus davidiana Planch" 생약학회지 27 (1): 26~31    
    4. 1996 "Purification and Properties of $\gamma$-Glutamyl Transpeptidase from Bacillus sp. KUN-17" Journal of microbiology and biotechnology 6 (4): 238~244    
    5. 1997 "Immunostimulating Activity of Polysaccharides from Mycelia of Phellinus linteus Grown under Different Culture Conditions" Journal of microbiology and biotechnology 7 (1): 52~55    
    6. 1997 "Neuronal Cell Protection Activity of Macrolactin A Produced by Actinomadura sp." Journal of microbiology and biotechnology 7 (6): 429~434    
    7. 1999 "Characterization of an Acidic Polysaccharide from Fruiting Bodies of Lyophyllum shimeji" Journal of microbiology and biotechnology 9 (2): 163~167    
    8. 1999 "Thelephoric acid and Kynapcin-9 in Mushroom Polyozellus multiflex Inhibit Prolyl Endopeptidase In Vitro" Journal of microbiology and biotechnology 9 (6): 798~803    
    9. 2000 "Two p-Terphenyls from Mushroom Paxillus panuoides with Free Radical Scavenging Activity" Journal of microbiology and biotechnology 10 (2): 233~237    
    10. 2000 "Lipid Peroxidation Inhibitory Activity of Some Constituents isolated from the Stem Bark of Eucalyptus globulus" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 23 (2): 147~150    

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기