본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Journal of microbiology and biotechnology v.15 no.2, 2005년, pp.434 - 437   피인용횟수: 2

Isolation of Sangivamycin from Streptomyces sp. A6497 and its Herbicidal Activity

HWANG EUI IL    (Bio Research Group, KT&G Central Research Institute   ); YUN BONG SIK    (Laboratory of Cellular Function Modulator, Korea Research Institute of Bioscience and Biotechnology   ); CHOI SUNG WON    (Research Institute of Biotechnology, Green Biotech Co.   ); KIM JIN SEOG    (Biofunction Research Team, Korea Research Institute of Chemical Technology   ); LIM SE JIN    (College of Pharmacy, Dongduk Women`s University   ); MOON JAE SUN    (Laboratory of Cellular Function Modulator, Korea Research Institute of Bioscience and Biotechnology   ); LEE SANG HAN    (Laboratory of Cellular Function Modulator, Korea Research Institute of Bioscience and Biotechnology   ); KIM SUNG UK    (Laboratory of Cellular Function Modulator, Korea Research Institute of Bioscience and Biotechnology  );
  • 초록

    During the screening for the inhibitors of cellulose biosynthesis as herbicides, we discovered a Streptomyces sp. A6497 with a selective antifungal activity against cellulose containing Phytophthora parasitica, but not against cellulose lacking Candida albicans. The inhibitor was isolated and identified, using a series of chromatographies. Based on structure analyses with UV spectrophotometry, mass and various NMR, the inhibitor was identified as sangivamycin. The compound exhibited strong antifungal activities against P. parasitica (MIC; 3.125 $\mu$ g/ml). In particular, it showed strong herbicidal activities against various weeds in the greenhouse experiment. Taken together, these results suggest that sangivamycin is a useful lead compound for the development of new herbicides.


  • 참고문헌 (20)

    1. Anzai, K., G. Nakamura, and S. Suzuki. 1957. A new antibiotic, tubercidin. J. Antibiot. 10A: 201- 204 
    2. Omura, S., Y. Tanaka, I. Kanaya, M. Shinose, and Y. Takahashi. 1990. Phthoxazolin, a specific inhibitor of cellulose biosynthesis, produced by a strain of Streptomyces sp. J. Antibiot. 43: 1024- 1036 
    3. Rao, K. V. 1968. Structure of sangivamycin, J. Med. Chem. 11: 939- 941 
    4. Suhadolnik, R. J., T. Uematsu, and H. Uematsu, 1967. Toyocarnycin: Phosphorylation and incorporation into RNA and DNA and the biochemical properties of triphosphate. Biochim. Biophys. Acta 149: 41- 49 
    5. Tanaka, Y., I. Kanaya, Y. Takahashi, M. Shinose, H. Tanaka, and S. Omura. 1993. Phthoxazolin A, a specific inhibitor of cellulose biosynthesis from Microbiol origin: I. Discovery, taxonomy of producing microorganism, fermentation, and biological activity. J. Antibiot. 46: 1208-1213 
    6. McGinnis, M. R. and M. G. Rinaldi 1986. Antifungal drugs: Mechanisms of action, drug resistance, susceptibility testing, and assays of activity in biological fluids, pp. 223- 281. ln V. Lorian (ed.), Antibiotics in Laboratory Medicine. Williams & Wilkins, Baltimore 
    7. Renau, T. E., L. L. Wotring, J. C. Drach, and L. B. Townsend. 1996. Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and thiosangivamycin: Influence of various 7-substituents on antiviral activity. J. Med. Chem. 39: 873-880 
    8. Omura, S., Y. Tanaka, K. Hisatome, S. Miura, Y. Takahashi, and A. Nakagawa. 1988. Phthoramycin, a new antibiotic active against a plant pathogen, Phytophthora sp. J. Antibiot. 41: 1910- 1912 
    9. Nishimura, H., K. Katagiri, K. Sato, M. Mayama, and N. Shimaoka. 1956. Toyocamycin, a new anti-Candida antibiotic. J. Antibiot. 9A: 60- 62 
    10. Koo, S. J., J. C. Neal, and J. M. DiTomaso. 1996. 3,7Dichloroquinolinecarboxylic acid inhibits cell wall biosynthesis in Maize roots. Plant Physiol. 112: 1383- 1389 
    11. Suhadolinik, R. J. 1970. Pyrrolopyrirnidine nucleosides, pp. 298- 353. In R. J. Suhadolinik (ed.), Nucleoside Antibiotics. John Wiley & Sons, New York, U.S.A 
    12. Hotchkiss, A. T. Jr. 1989. Cellulose biogenesis and structure, pp. 232- 298. In N. G. Lewis and M. G. Paice (eds.), Plant Cell Wall Polymers: Biogenesis and Biodegradation. ACS Press, Washington, D.C., U.S.A 
    13. Locci, R. 1989. Streptomycetes and related genera, pp. 2451- 2492. In S. T. Williams, M. E. Sharpe, and J. G. Holt (eds.), Bergey's Manual of Systematic Bacteriology, Vol. 4. Williams and Wilkins, Baltimore 
    14. Hopp, H. E., P. A. Romero, and R. Pont-Lezica. 1978. On the inhibition of cellulose biosynthesis by coumarin. FEBS Lett. 86: 259- 262 
    15. Okuda, S. 1992. Herbicides, pp. 224- 236. In S. Omura (ed.) The Search for Bioactive Compounds from Microorganisms. Springer-Verlag, Berlin 
    16. Osada, H., T. Sonoda, K. Tsunoda, and K. Isono, 1989. A new biological role of sangivamycin: Inhibition of protein kinases. J. Antibiot. 42: 102- 106 
    17. Bartnicki-Garcia, S. and M. C. Wang. 1983. Biochemical aspects of morphogenesis in Phytophthora, pp. 121- 137. In D. C. Erwin (ed.), Phytophthora; Its Biology, Taxonomy, Ecology, and Pathogenicity; American Phytopathological Society, Minnesota, U.S.A 
    18. Cabib, E., J. A. Shaw, P. C. Mol, B. Bower, and W. J. Choi. 1996. Chitin biosynthesis and morphogenetic process, pp. 243- 267. In R. Bramal and G, A. Marzluf (eds.), The Mycota; Biochemistry and Molecular Biology; Vol. 3, SpringerVerlag, Berlin 
    19. Ruiz-Herrera, J. 1992. Fungal Cell Wall: Structure, Synthesis and Assembly, pp. 5- 57. CRC Press, Boca Raton 
    20. Suhadolnik, R. J., T. Uematsu, H. Uematsu, and R. G. Wilson. 1968. The incorporation of sangivamycin 5'-triphosphate into polyribonucleotide by ribonucleic acid polymerase from Micrococcus lysodeikticus. J. Biol. Chem. 243: 2761- 2766 
  • 이 논문을 인용한 문헌 (2)

    1. 2006. "" Journal of microbiology and biotechnology, 16(9): 1472~1476     
    2. 2007. "" Journal of microbiology and biotechnology, 17(8): 1385~1389     

 저자의 다른 논문

  • Moon, Jae-Sun (10)

    1. 2003 "WRKY Transcription Factor Family in Plant Defense Mechanism" The plant pathology journal 19 (1): 9~12    
    2. 2004 "시설 및 노지재배 고추의 바이러스병 발생과 분포" Research in plant disease = 식물병연구 10 (4): 231~240    
    3. 2004 "유전자 변형 작물 성분 검출용 PCR Kit의 성능 평가 연구" Journal of toxicology and public health : an official journal of the Korean Society of Toxicology 20 (2): 101~108    
    4. 2005 "Isolation of Candida albicans Chitin Synthase 1 Inhibitor from Streptomyces sp. A6705 and Its Characterization" Journal of microbiology and biotechnology 15 (4): 895~898    
    5. 2005 "Compound IKD-8344, a Selective Growth Inhibitor Against the Mycelial Form of Candida albicans, Isolated from Streptomyces sp. A6792" Journal of microbiology and biotechnology 15 (4): 909~912    
    6. 2005 "Investigation of Possible Horizontal Gene Transfer from the Leaf Tissue of Transgenic Potato to Soil Bacteria" Journal of microbiology and biotechnology 15 (5): 1130~1134    
    7. 2006 "콩(Glycine max)에서 콩위축바이러스(Soybean dwarf virus)의 최초 발생보고" Research in plant disease = 식물병연구 12 (3): 213~220    
    8. 2013 "영세농가 콩 재배지의 Soybean mosaic virus, Soybean yellow mottle mosaic virus 및 Soybean yellow common mosaic virus 병 발생 조사" Research in plant disease = 식물병연구 19 (4): 319~325    
    9. 2018 "Beet western yellows virus (BWYV): Aspect of Outbreak and Survey, and First Complete Genome Sequence of a Korea Isolate of BWYV" Research in plant disease = 식물병연구 24 (4): 276~284    
  • Kim, Sung-Uk (13)

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기