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Macromolecular research v.13 no.3, 2005년, pp.167 - 175   피인용횟수: 2

Self-Assembled Nanoparticles of Bile Acid-Modified Glycol Chitosans and Their Applications for Cancer Therapy

Kim Kwangmeyung    (Biomedical Research Center, Korea Institute of Science and Technology, KIST Regional Laboratory in Advanced Medical Technology Cluster for Diagnosis & Prediction   ); Kim Jong-Ho    (Biomedical Research Center, Korea Institute of Science and Technology, KIST Regional Laboratory in Advanced Medical Technology Cluster for Diagnosis & Prediction   ); Kim Sungwon    (Biomedical Research Center, Korea Institute of Science and Technology   ); Chung Hesson    (Biomedical Research Center, Korea Institute of Science and Technology   ); Choi Kuiwon    (Biomedical Research Center, Korea Institute of Science and Technology   ); Kwon Ick Chan    (Biomedical Research Center, Korea Institute of Science and Technology, KIST Regional Laboratory in Advanced Medical Technology Cluster for Diagnosis & Prediction   ); Park Jae Hyung    (Department of Advanced Polymer and Fiber Materials, College of Environment and Applied Chemistry, Kyung Hee University   ); Kim Yoo-Shin    (Department of Biochemistry, School of Medicine, Kyungpook National University, Advanced Medical Technology Cluster for Diagnosis & Prediction   ); Park Rang-Won    (Department of Biochemistry,  ); Kim In-San   Jeong Seo Young  
  • 초록

    This review explores recent works involving the use of the self-assembled nanoparticles of bile acid-modified glycol chitosans (BGCs) as a new drug carrier for cancer therapy. BGC nanoparticles were produced by chemically grafting different bile acids through the use of l-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC). The precise control of the size, structure, and hydrophobicity of the various BGC nanoparticles could be achieved by grafting different amounts of bile acids. The BGC nanoparticles so produced formed nanoparticles ranging in size from 210 to 850 nm in phosphate-buffered saline (PBS, pH=7.4), which exhibited substantially lower critical aggregation concentrations (0.038-0.260 mg/mL) than those of other low-molecular-weight surfactants, indicating that they possess high thermodynamic stability. The SOC nanoparticles could encapsulate small molecular peptides and hydrophobic anticancer drugs with a high loading efficiency and release them in a sustained manner. This review also highlights the biodistribution of the BGC nanoparticles, in order to demonstrate their accumulation in the tumor tissue, by utilizing the enhanced permeability and retention (EPR) effect. The different approaches used to optimize the delivery of drugs to treat cancer are also described in the last section.


  • 주제어

    glycol chitosan .   nanoparticle .   EPR effect .   cancer therapy.  

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  • 이 논문을 인용한 문헌 (2)

    1. 2008. "" Macromolecular research, 16(1): 15~20     
    2. 2008. "" Macromolecular research, 16(1): 57~61     

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