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Pycnogenol Supplementation Retards Immune Dysfunction in Murine AIDS (MAIDS) After LP-BM5 Leukemia Virus Infection by Modulating Cytokine Secretion

Lee, Jeong-Min    (Department of Food and Life Sciences, Nambu University   ); Park, Kun-Young    (Department of Food and Nutrition, Pusan National University   ); Hwang, Kwon-Tack    (Department of Food and Life Sciences, Nambu University   ); Watson, Ronald R.    (Division of Health Promotion Sciences, Mel and Enid Zuckerman, College of Public Health, University of Arizona  );
  • 초록

    We investigated the effect of pycnogenol (PYC) supplementation on retarding the immune dysfunction of CS7BL/6 mice after murine AIDS (MAIDS) development. Dysfunction of T and B cell mitogenesis from primary cultured splenocytes has been observed with retrovirus infection and PYC supplementation partially recovered the dysfunction of T and B cells. There was an abnormal shift of cytokine pattern with retrovirns infection, which was designated by the decreased secretion of Th1 cytokines and increased secretion of Th2 cytokines. PYC supplementation increased IL-2 and $IFN-\gamma$ secretion and decreased IL-4, IL-6, and $TNF-\alpha$ secretion, but it was not sufficient enough to maintain the normal level of these cytokines. Hepatic vitamin E level was significantly decreased by retrovirns infection, in accordance with increased hepatic lipid peroxidation level, whereas PYC supplementation normalized the hepatic level of vitamin E and lipid peroxidation. This study suggests that PYC supplementation may partially help retard the incidence of symptoms during MAIDS.


  • 주제어

    pycnogenol .   murine AIDS .   cytokines .   mitogenesis .   lipid peroxidation.  

  • 참고문헌 (21)

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