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Journal of food science and nutrition v.10 no.2, 2005년, pp.167 - 171   피인용횟수: 2

Doenjang Extract Has Anticancer Activity and Induces Apoptosis in AGS Human Gastric Adenocarcinoma

Hwang, Kyung-Mi    (Department of Food Science and Nutrition, Pusan National University   ); Lee, Jeong-Min    (Department of Food and Life Sciences, Nambu University   ); Park, Kun-Young    (Department of Food Science and Nutrition, Pusan National University  );
  • 초록

    The anticancer and apoptotic effect of chloroform extract from 24 month-fermented doenjang were investigated in AGS human gastric adenocarcinoma cells. The chloroform extract of 24 month-fermented doenjang inhibited the AGS gastric cancer cell growth in a dose-dependent manner. It has been confirmed by observing the cell distribution under inverted microscope. Approximately, 48 hour treatment of $100\;{\mu}g/mL$ doenjang extract inhibited AGS cancer cell growth by $76.7\%$ , respectively. The growth inhibition may be caused by apoptosis of AGS cancer cells after 48 hour treatment of 24 month-fermented doenjang extract. It has been demonstrated by cell cycle arrest that revealed the shift from $G_2+M\;to\;G_0+G_1$ phase and the formation of apoptotic bodies. The fermentation period playa critical role in cell cycle arrest, in which 24 month-fermented doenjang extract was more effective than 12 month-fermented doenjang extract. The treatment of 24 month-fermented doenjang extract for 48 hours has induced intercellular Bax and decreased Bcl-2 level, indicating that it may regulate the expression level of Bax/Bcl-2 proteins. Thus, 24 month-fermented doenjang extract seems to have anticancer effect via cancer cell growth inhibition induced by apoptosis process.


  • 주제어

    doenjang .   anticancer .   AGS adenocarcinoma .   growth inhibition .   apoptosis.  

  • 참고문헌 (14)

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  • 이 논문을 인용한 문헌 (2)

    1. Hwang, Joon-Ho ; Oh, You-Sung ; Lim, Ja-Hun ; Park, Ji-Eun ; Kim, Mi-Bo ; Yoon, Hoon-Seok ; Lim, Sang-Bin 2009. "Physiological Properties of Jeju Traditional Doenjang" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 38(12): 1656~1663     
    2. Lee, Sun-Mi ; Chang, Hae-Choon 2009. "Growth-inhibitory Effect of the Solar Salt-Doenjang on Cancer Cells, AGS and HT-29" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 38(12): 1664~1671     

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