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Peripheral Nerve Injury Alters Excitatory and Inhibitory Synaptic Transmission in Rat Spinal Cord Substantia Gelatinosa

Youn, Dong-Ho    (Department of Oral Physiology, School of Dentistry, Kyungpook National University  );
  • 초록

    Following peripheral nerve injury, excessive nociceptive inputs result in diverse physiological alterations in the spinal cord substantia gelatinosa (SG), lamina II of the dorsal horn. Here, I report the alterations of excitatory or inhibitory transmission in the SG of a rat model for neuropathic pain ('spared nerve injury'). Results from whole-cell recordings of SG neurons show that the number of distinct primary afferent fibers, identified by graded intensity of stimulation, is increased at 2 weeks after spared nerve injury. In addition, short-term depression, recognized by paired-pulse ratio of excitatory postsynaptic currents, is significantly increased, indicating the increase of glutamate release probability at primary afferent terminals. The peripheral nerve injury also increases the amplitude, but not the frequency, of spontaneous inhibitory postsynaptic currents. These data support the hypothesis that peripheral nerve injury modifies spinal pain conduction and modulation systems to develop neuropathic pain.


  • 주제어

    Spinal substantia gelatinosa .   Synaptic transmission .   Neuropathic pain .   Spared nerve injury.  

  • 참고문헌 (26)

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 저자의 다른 논문

  • Youn, Dong-Ho (2)

    1. 2015 "Spinal Gap Junction Channels in Neuropathic Pain" The Korean journal of pain 28 (4): 231~235    
    2. 2017 "Pain in Animals: Anatomy, Physiology, and Behaviors" Journal of veterinary clinics = 한국임상수의학회지 34 (5): 347~352    

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