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Preventive Effect of Serotonergic Drugs on LPS-Induced Acute Anorexia in Rats

Park, So-Young    (Departments of Physiology, College of Medicine, Yeungnam University   ); Kim, Keon-Ho    (Departments of Orthopedic Surgery, College of Medicine, Yeungnam University   ); Ahn, Dong-Kuk    (Deportment of Oral Physiology, School of Dentistry, Kyungpook National University   ); Park, Tae-Im    (Departments of Physiology, College of Medicine, Yeungnam University   ); Kim, Jong-Yeon    (Departments of Physiology, College of Medicine, Yeungnam University   ); Kim, Yong-Woon    (Departments of Physiology, College of Medicine, Yeungnam University   ); Lee, Dong-Chul    (Departments of Orthopedic Surgery, College of Medicine, Yeungnam University   ); Lee, Suck-Kang    (Departments of Physiology, College of Medicine, Yeungnam University  );
  • 초록

    The aim of the present study was to determine whether serotonergic drugs could reverse lipopolysaccharide (LPS)-induced anorexia in rats. LPS ( $500{\mu}g$ /kg body weight) and all serotonergic drugs, except for 8-OH-DPAT (subcutaneous), were injected intraperitoneally into Sprague-Dawley rats. Without the LPS injection, 8-OH-DPAT (1A agonist), metergoline (1/2 antagonist), and mianserin (2A/2C antagonist) exerted no effects on food intake at any of the doses tested, but ketanserin (2A antagonist) caused an increase of food intake at 4 mg/kg. RS-102221 (2C antagonist) reduced food intake at 2 and 4 mg/kg. LPS reduced food intake 1 hour after injection, and food intake remained low until the end of measurement period (24 hours) (p

  • 주제어

    Lipopolysaccharide .   Anorexia .   Serotonin .   Serotonergic drug .   Rat.  

  • 참고문헌 (35)

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