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Natural product sciences v.11 no.1, 2005년, pp.22 - 26   피인용횟수: 1

Free Radical Scavenging and Lipid Peroxidation Inhibition Potential of Hygrophila auriculata

Vijayakumar, Madhavan    (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute   ); Govindarajan, Raghavan    (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute   ); Shirwaikar, Arun    (College of Pharmaceutical sciences, MAHE   ); Kumar, Vivek    (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute   ); Rawat, Ajay Kumar Singh    (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute   ); Mehrotra, Shanta    (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute   ); Pushpangadan, Palpu    (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute  );
  • 초록

    Hygrophila auriculata (K. Schum.) Heine is a wild herb commonly found in moist places on the banks of tanks, ditches and paddy fields throughout India and is one of the main sources of Ayurvedic 'Rasayana' drug. The free radical scavenging potential of 50% aqueous alcoholic extract of H. auriculata (HAEt) was studied for DPPH scavenging activity, nitric oxide, hydroxyl radical and ferryl bipyridyl complex scavenging activity along with lipid peroxidation and total antioxidant capacity inhibition using Thiobarbituric acid reactive substances (TBARS) in rat liver homogenate. Integral antioxidative capacity was determined by photochemiluminescence assay. HAEt showed good radical scavenging activity at various concentrations $(200-1000\;{\mu}g/ml)$ against 1,1 diphenyl, 2-picrylhydrazyl (DPPH) (32.32-77.02%) with moderate scavenging activity against Nitric oxide (12.46-52.84%), hydroxyl radical (11.69-55.26%), ferryl bipyridyl complex (17.66-58.67%) and lipid peroxidation (0.829-0.416nmoles/mg protein). The above results indicate HAEt to be very effective antioxidant. It was suggested that the varied therapeutic activities claimed for the plant in the Indian indigenous systems of medicine may be in the part due to the free radical scavenging and/ or potent antioxidant activity.

  • 주제어

    Hygrophila auriculata .   free radical scavenging .   Lipid peroxidation .   Photochemiluminescence assay.  

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  • 이 논문을 인용한 문헌 (1)

    1. Kim, Eun-Mi ; Won, Sun-Im 2009. "Functional Composition and Antioxidative Activity from Different Organs of Native Cirsium and Carduus Genera" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 25(4): 406~414     

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