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Natural product sciences v.11 no.1, 2005년, pp.27 - 32   피인용횟수: 1

Inhibitory Effects of Resina Pini on the Growth and Glucosyltransferase activity of Streptococcus mutans

Seo, Young-A    (College of Pharmacy, Catholic University of Daegu   ); Choi, Nam-Ju    (College of Pharmacy, Catholic University of Daegu   ); Suk, Kui-Duk    (College of Pharmacy, Catholic University of Daegu  );
  • 초록

    The purpose of this study is to evaluate the inhibitory effects of Resina Pini against Streptococcus mutans (S. mutans) that is one of the major causes of dental caries and oral diseases. Topically applied Resina Pini (RP) would be incorporated in saliva and thus the factor associated with water solubility should be considered. In this paper, therefore, effects of various treatment for RP and activities of water extracts from unprocessed and processed RP were compared. The crude RP (RP1) and the recrystallized RP (RP2) in ethanol solution showed strong antimicrobial activities (d.>15mm) against S. mutans. All RP samples exhibited considerable inhibitory effect against glucosyltransferase produced by S. mutans $(IC_{50}=91.2\;to\;276.2\;{\mu}g/ml)$ . The very considerable increase in cellular permeability of S. mutans was observed with RP1, RP2 and their water extracts. These results suggest that RP1 and RP2 may be a potential source for pharmaceutical products used for prevention and/or treatment of dental caries and periodontal disease.


  • 주제어

    Resina Pini .   glucosyltransferase .   Streptococcus mutans .   periodontal disease .   Cellular permeability.  

  • 참고문헌 (21)

    1. Bacca, L.A, Leusch, M., Lanzalaco, A.C., Macksood D., Bouwsma O.J., Shaffer J.B., Howard-Nordan K.S., Knippenberg S.H., Kreutzjans M.K., Miller lM., Poore C.L., Sunberg R.J., Vastola K.A Becus M., Bartizek R.D., Block R. P, Briner W.W, and White D.J., A comparison of intraoral antimicrobial effects of stabilized stannous fluoride dentifrice, baking soda/peroxide dentifrice, conventional NaP dentifrice and essential oil mouthrinse. J. Clin. Dent. 8, 54-61 (1997) 
    2. Banas, J.A, Virulence properties of Streptococcus mutans. Front. Biosci. 9, 1267-77 (2004) 
    3. Harvey, A, Strategies for discovering drugs from previously unexplored natural products. Drug Discov. Today, 5, 294-300 (2000) 
    4. Kwon, J.B., Lee, Y.W, An, B.J., and Lee, S.Y., Inhibitory effection of cacao bean husk extract on glucosyltransferase from Streptococcus mutans B13. Kor. J. Biotechnol. Bioeng. 8, 75-82 (1993) 
    5. Kim, C.M., The pharmacognosy. The Korean pharmaceutical association, Seoul, 1995 
    6. Park, C.S., and Shin, Y.'S., Effect of Phellodendri cortex L. on the activity of glucosyltransferase and human gingival cell, growth and membrane permeability of Streptococcus mutans JC-2. J. Korean Acad. Dent. Health 19, 447-456 (1995) 
    7. Schwach-Abdellaoui, K., Loup, P.J, Vivien-Castioni, N., Mombelli, A., Baehni, P., Barr, L, Heller, L, and Gumy, R, Bioerodible injectable poly (ortho ester) for tetracycline controlled delivery to periodontal pockets: preliminary trial in humans. AAPS PharmSci. 4, 20 (2002) 
    8. Tsumori, H., and Kurarnitsu, H., The role of the Streptococcus mutans glucosyltransferases in the sucrose-dependent attachment to smooth surfaces: essential role of the GtfC enzyme. Oral Microbiol. Immunol. 12, 274-280 (1997) 
    9. National Committee for Clinical Laboratory Standards. Performance Standards for Antimicrobial Disk Susceptibility Tests-Sixth Edition; Approved Standard. NCCLS Vol. 19 No.1 (1999) 
    10. Tanzer, J,M., On changing the cariogenic chemistry of coronal plaque. J. Dent. Res. 68, 1576-1587 (1989) 
    11. Yun, S.O., Fine tree and naturopathy, Academy press, Korea, 1997 
    12. Goodson, J.M., Antimicrobial strategies for treatment of periodontal diseases. Periodontology 5, 142-168 (1994) 
    13. Yanagida, A., Kanda, T., Tanabe M., Matsudaira E, and Oliveira Cordeiro J.G., Inhibitory effects of apple polyphenols and related compounds on cariogenic factors of mutans streptococci. J. Agric. Food Chem. 48, 5666-71 (2000) 
    14. Wu-Yuan, C.D., Gallotannins inhibit growth, water-soluble glucan synthesis and aggregation of Mutans streptococci. J. Dent. Res. 67, 51-55 (1988) 
    15. Park, W.J., Lee, H.J., and Yang, S.K., The inhibitory Effect of Sanggenon C from the Root-bark of Morus alba L. on the Growth and the Cellular Adherence of Streptococcus mutans. J. Korean pharm. 34, 434-438 (1990) 
    16. Lee, H.O., Han, D.M., and Baek, S.H., Isolation and identification of anticariotic compound from Sophora flavescens Ait. Kor. J. Microbiol. Biotechnol. 30, 420-424 (2002) 
    17. Namba, T., The encyclopedia of Wakan-Yaku, Vol. II, Hoikusa, Japan, 1980 
    18. Mombelli, A, Periodontitis as an infectious disease: specific features and their implications. Oral Dis. 9, 6-10 (2003) 
    19. Song, H.K., and Kim, J.K; Essential oil components of leaves and resins from Pinus densiflora and Pinus koraiensis. Mokchae Konghak 22, 55-67 (1994) 
    20. Nyvad, B., and kilian, M., Microbiology of the early colonization of human enamel and root surface in vivo, Scand. J. Dent. Res. 95, 369-380 (1987) 
    21. Trombelli, L., and Tatakis, D.N., Periodontal diseases: current and future indications for local antimicrobial therapy. Oral. Dis. 9, 11-5 (2003) 
  • 이 논문을 인용한 문헌 (1)

    1. 2007. "" Natural product sciences, 13(4): 347~354     

 저자의 다른 논문

  • Seo, Young-A (1)

    1. 2007 "Analgesic and Anti-inflammatory Activity of Resina Pini" Natural product sciences 13 (4): 347~354    

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