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Natural product sciences v.11 no.2, 2005년, pp.79 - 84   피인용횟수: 1

Coumarins and Chromones from Angelica genuflexa

An, Ren-Bo    (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology,College of Pharmacy, Yanbian, University   ); Park, Bo-Young    (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology   ); Kim, Jung-Hee    (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology   ); Kwon, Ok-Kyoung    (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology   ); Lee, Joong-Ku    (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology   ); Min, Byung-Sun    (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology   ); Ahn, Kyung-Seop    (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology   ); Oh, Sei-Ryang    (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology   ); Lee, Hyeong-Kyu    (Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology  );
  • 초록

    Thirteen compounds were isolated from the roots of Angelica genuflexa through repeated silica gel column chromatography. Nine coumarins, isoimperatorin (1), osthol (2), demethylsuberosin (3), oxypeucedanin (4), heraclenin (5), pabulenol (7), umbelliferone (8), oxypeucedanin hydrate (9) and marmesinin (11), and four chromones, hamaudol (6), cimifugin (10), sec-O-glucosylhamaudol (12) and prim-O-glucosylcimifugin (13), were identified by physicochemical and spectroscopic analysis. Among these, compounds 3, 5, 6, 8, 12, and 13 were isolated for the first time from the roots of Angelica genuflexa. These coumarins and chromones were examined for their anticomplement activity. Demethylsuberosin (3) showed a weak anticomplement activity with an $IC_{50}$ value of $390\;{\mu}M$ .


  • 주제어

    Angelica genuflexa .   demethylsuberosin .   heraclenin .   hamaudol .   umbelliferone .   sec-O-glucosylhamaudol .   prim-O-glucosylcimifugin .   anticomplement activity.  

  • 참고문헌 (19)

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    18. Min, B.S., Lee, S.Y., Kim, J.H., Lee, J.K., Kim, T.J., Kim, D.H., Kim, Y.H., Joung, H., Lee, H.K, Nakamura, N., Miyashiro, H., and Hattori, M., Anti-complement activity of constituents from the stem-bark of Juglans mandshurica. Biol. Pharm. Bull., 26, 1042-1044 (2003) 
    19. Ryu, K.S., The chemical structure of koreanin isolated from the roots Angelica koreana Maximowicz. Yakhak Hoeji 12, 65-71 (1968) 
  • 이 논문을 인용한 문헌 (1)

    1. 2006. "" Natural product sciences, 12(3): 129~133     

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