본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Natural product sciences v.11 no.2, 2005년, pp.85 - 88   피인용횟수: 3

Inhibitory Constituents of LPS-induced Nitric Oxide Production from Arctium lappa

Park, So-Young    (College of Pharmacy, Chungbuk National University   ); Hong, Seong-Su    (College of Pharmacy, Chungbuk National University   ); Han, Xiang-Hua    (College of Pharmacy, Chungbuk National University   ); Ro, Jai-Seup    (College of Pharmacy, Chungbuk National University   ); Hwang, Bang-Yeon    (College of Pharmacy, Chungbuk National University  );
  • 초록

    The methanolic extract from the seeds of Arctium lappa was found to inhibit the LPS-induced nitric oxide (NO) production in murine macrophage RAW264.7 cells. Bioassay-guided fractionation of a methylene chloride soluble fraction led to the isolation of three lignan compounds, arctiin (1), arctigenin (2), and lappaol B (3). Their structures were elucidated by UV, IR, MS, and NMR data, as well as by comparison with those of the literatures. Arctigenin (2) and lappaol B (3) had an iNOS inhibitory activity with $IC_{50}$ values of 12.5 and $25.9\;{\mu}M$ , respectively.


  • 주제어

    Arctium lappa .   Compositae .   Lignan .   Nitric oxide synthase inhibitor.  

  • 참고문헌 (18)

    1. Cho, M.K., Jang, Y.P., Kim, Y.C., and Kim, S.G. Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-${\alpha}$ inhibition. Int. Immunopharmacol. 4, 1419-1429 (2004) 
    2. Ichihara, A, Numata, Y., Kanai, S., and Sakamura, S., New sesquilignans from Arctium lappa L. The structure of lappaol C, D and E. Agric. Biol. Chem. 41, 1813-1814 (1977) 
    3. Ichihara, A., ada, K., Numata, Y., and Sakamura, S., Lappaol A and B, novel lignans from Arctium lappa. Tetrahedron Lett. 17,3961-3964 (1976) 
    4. Iwakami, S., Wu, J.B., Ebizuka, Y., and Sankawa, U., Platelet activating factor (PAP) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem. Pharm. Bull. 40, 1196-1198 (1992) 
    5. Moncada, S., Palmer, R.M., and Higgs, E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43, 109-142 (1991) 
    6. Tundis, R., Statti, G., Menichini, F., and Delle Monache, F. Arctiin and onopordopicrin from Carduus micropterus ssp. perspinosus. Fitoterapia 71, 600-601 (2000) 
    7. Schmidt, H. H. H. W., and Kelm, M. Determination of nitrite and nitrate by the Griess reaction. In: Methods in Nitric Oxide Research. John Wiley & Sons Ltd., London, 1996, pp. 491-497 
    8. Ichihara, A, Nakamura, Y., Kawagishi, H., and Sakamura, S., Stereochemistry of lappaol A and F. Tetrahedron Lett. 20, 3735-3738 (1979) 
    9. Umehara, K., Sugawa, A., Kuroyanagi, M., Ueno, A., and Taki, T. Studies on differentiation-inducers from Arctium fructus. Chem. Pharm. Bull. 41, 1774-1779 (1993) 
    10. Cho, M.K., Park, J.W., Jang, Y.P., Kim, Y.C., and Kim, S.G. Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-${\kappa}B{\alpha}$ phosphorylation and of p65 nuclear translocation in macrophages. Int. Immunopharmacol. 2, 105-116 (2002) 
    11. Koubaa, I., Damak, M., McKillop, A., and Simmonds, M. Constituents of Cynara cardunculus. Fitoterapia 70, 212-213 (1999) 
    12. Umehara, K., Nakamura, M., Miyase, T., Kuroyanagi, M., and Ueno, A Studies on differentiation inducers. VI. Lignan derivatives from Arctium fructus. (2). Chem. Pharm. Bull. 44, 2300-2304 (1996) 
    13. Cho J.Y., Kim, A.R., Yoo, E.S., Baik, K.U., and Park, M.H., Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-a and nitric oxide production, and lymphocyte proliferation. J. Pharm. Pharmacol. 51, 1267-1273 (1999) 
    14. Scudiero, D.A., Shoemaker, R.H., Paull, K.D., Monks, A., Tierney, S., Nofziger, T.H., Currens, M.J., Seniff, D., and Boyd, M.R. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res. 48, 4827-4833 (1988) 
    15. Jung, B.S. and Shin, M.K., Encyclopedia of illustrated Korean natural drugs. Young Lim Sa, Seoul, 1989, pp.1010-1012 
    16. Ichihara, A., Kanai, S., Nakamura, Y., and Sakamura, S., Structures of lappaol F and H, dilignans from Arctium lappa. Tetrahedron Lett. 19, 3035-3038 (1978) 
    17. Han, B.H., Kang, Y.H., Yang, H.O., and Park, M.K., A butyrolactone lignan dimer from Arctium lappa. Phytochemistry 37, 1161-1163 (1994) 
    18. Anggard, E. Nitric oxide: mediator, murderer, and medicine. Lancet 343, 1199-1206 (1994) 
  • 이 논문을 인용한 문헌 (3)

    1. 2006. "" Natural product sciences, 12(4): 221~225     
    2. 2011. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 34(9): 1459~1466     
    3. Kim, Mi-Sun ; Lee, Ye-Seul ; Sohn, Ho-Yong 2014. "Anti-thrombosis and anti-oxidative activity of the root of Arctium lappa L." 한국식품저장유통학회지 = Korean journal of food preservation, 21(5): 727~734     

 저자의 다른 논문

  • Hong, Seong-Su (22)

    1. 2001 "익모초로부터 Leonurine의 분리 및 함량분석" 생약학회지 32 (4): 322~326    
    2. 2001 "오가피로부터 Acanthoside D의 분리 및 함량분석" 생약학회지 32 (4): 316~321    
    3. 2001 "음나무 수피의 화학적 성분" 생약학회지 32 (4): 302~306    
    4. 2002 "산사자의 Monoamine Oxidase 활성 저해 성분" 생약학회지 33 (4): 285~290    
    5. 2002 "해동피로부터 Kalopanax-saponin B의 분리 및 함량분석" 생약학회지 33 (4): 277~284    
    6. 2005 "Monoamine Oxidase Inhibitor from Uncaria rhynchophylla" Natural product sciences 11 (3): 145~149    
    7. 2005 "Antioxidant Constituents from Portulaca oleracea" Natural product sciences 11 (4): 229~232    
    8. 2005 "수확 후 광 노출이 삼백초 품질변화에 미치는 영향" 韓國資源植物學會誌 = Korean journal of plant resources 18 (3): 505~511    
    9. 2005 "Monoamine Oxidase Inhibitory Constituents from the Fruits of Cudrania tricuspidata" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 28 (12): 1324~1327    
    10. 2005 "Induction of Neurite Outgrowth by (-)-(7R, 8S)-Dihydrodehyd­rodiconiferyl Alcohol from PC12 Cells" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 28 (12): 1337~1340    
  • Han, Xiang Hua (11)

  • 노재섭 (55)

  • Hwang, Bang-Yeon (70)

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • NDSL :
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기