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Natural product sciences v.11 no.2, 2005년, pp.89 - 91  

Honokiol : A Noncompetitive Tyrosinase Inhibitor from Magnoliae Cortex

Tian, Yu-Hua    (Phytofermentation Research Center and College of Pharmacy, Wonkwang University   ); Kang, Tai-Hyun    (Phytofermentation Research Center and College of Pharmacy, Wonkwang University   ); Kim, Hyun-Chul    (Phytofermentation Research Center and College of Pharmacy, Wonkwang University   ); Kim, Youn-Chul    (Phytofermentation Research Center and College of Pharmacy, Wonkwang University  );
  • 초록

    Effect of the neolignans, honokiol (1) and magnolol (2), isolated from Magnoliae Cortex on mushroom tyrosinase activity was investigated in vitro using L-tyrosine as a substrate. Honokiol (1) inhibited tyrosinase activity significantly in a concentration-dependent manner, on the other hand, magnolol (2) did not show tyrosinase inhibitory effect. Honokiol exhibited tyrosinase inhibitory effect with $IC_{50}$ value of $67.9\;{\mu}M$ , and proved to act as a non-competitive inhibitor by the analysis of Lineweaver-Burk plot.


  • 주제어

    Honokiol .   Tyrosinase inhibitor .   Magnoliae Cortex.  

  • 참고문헌 (13)

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    13. Tsai, S.K., Huang, C.H., Huang, S.S., Hung, L.M., and Hong, C.Y., Antiarrhythmic effect of magnolol and honokiol during acute phase of coronary occlusion in anesthetized rats: influence of L-NAME and aspirin. Pharmacology 59, 227-233 (1999) 

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