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Antiarrhythmic Effects of KR-32570, a Novel Na+-H+ Exchanger Inhibitor, on Ischemia/Reperfusion-Induced Arrhythmias

Hwang, Geum-Shil    (Medicinal Science Division, Korea Research Institute of Chemical Technology   ); Seo, Ho-Won    (Medicinal Science Division, Korea Research Institute of Chemical Technology   ); Lee, Kyu-Yang    (Medicinal Science Division, Korea Research Institute of Chemical Technology   ); Lee, Sun-Kyung    (Medicinal Science Division, Korea Research Institute of Chemical Technology   ); Yoo, Sung-Eun    (Medicinal Science Division, Korea Research Institute of Chemical Technology   ); Lee, Byung-Ho    (Medicinal Science Division, Korea Research Institute of Chemical Technology  );
  • 초록

    The present study was performed to evaluate antiarrhythmic effects of KR-32570, a novel inhibitor of sodium hydrogen exchanger subtype-1 (NHE-1), in rat arrhythmia induced by focal ischemia and reperfusion. During ischemia, KR-32570 significantly decreased the number of premature ventricular contraction (PVC) from 152.0 times to 75.5, 52.4 and 20.0 times for 0.1, 0.3 and 1.0 mg/kg, respectively (p


  • 주제어

    antiarrhythmic effect .   sodium hydrogen exchanger .   KR-32570.  

  • 참고문헌 (32)

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