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Isoliquiritigenin : A Competitive Tyrosinase Inhibitor from the Heartwood of Dalbergia odorifera

Kang, Tai-Hyun    (College of Pharmacy and Phytofermentation Research Center, Wonkwang University   ); Tian, Yu-Hua    (College of Pharmacy and Phytofermentation Research Center, Wonkwang University   ); Kim, Youn-Chul    (College of Pharmacy and Phytofermentation Research Center, Wonkwang University  );
  • 초록

    Effect of isoliquiritigenin isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) on mushroom tyrosinase activity was investigated in vitro using L-tyrosine and L-3, 4-dihydroxyphenylalanine (L-DOPA) as the substrates. When L-tyrosine was used as a substrate, both isoliquiritigenin and kojic acid, a positive control, inhibited tyrosinase activity in a concentration-dependent manner. IC $_{50}$ values of isoliquiritigenin and kojic acid were 61.4 and 52.2 ${\muM}$ , respectively. However, isoliquiritigenin showed week inhibitory effect on the oxidation of L-DOPA by tyrosinase with inhibition ratio of 9.1 ${\pm}$ 7.1% at 100 ${\muM}$ . It is also suggested that 3-unsubstituted and 4-hydroxyl phenyl group in isoliquiritigenin plays an important role on the inhibition of tyrosinase activity when L-tyrosine was used as a substrate. Analysis of Lineweaver-Burk plot showed that isoliquiritigenin acts as a competitive inhibitor in case of L-tyrosine as a substrate.


  • 주제어

    Dalbergia odorifera .   isoliquiritigenin .   L-tyrosine .   L-DOPA .   tyrosinase inhibitor.  

  • 참고문헌 (12)

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  • 이 논문을 인용한 문헌 (1)

    1. 2009. "" Journal of the Korean Society for Applied Biological Chemistry, 52(4): 375~379     

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  • Kim, Youn-Chul (66)

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