본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Journal of microbiology and biotechnology v.15 no.3, 2005년, pp.646 - 651   피인용횟수: 6

Antimicrobial Activity of Quinoline Derivatives Isolated from Ruta chalepensis Toward Human Intestinal Bacteria

CHO JANG-HEE    (Research Center for Industrial Development of Biofood Materials and Faculty of Biotechnology, College of Agriculture & Life Science, Chonbuk National University   ); LEE CHI-HOON    (Research Center for Industrial Development of Biofood Materials and Faculty of Biotechnology, College of Agriculture & Life Science, Chonbuk National University   ); LEE HOI-SEON    (Research Center for Industrial Development of Biofood Materials and Faculty of Biotechnology, College of Agriculture & Life Science, Chonbuk National University  );
  • 초록

    The growth responses of Ruta chalepensis leaf-derived materials toward human intestinal bacteria were examined. The biologically active constituent of the R. chalepensis extract was characterized as quinoline-4-carboxaldehyde( $C_{10}H_{7}NO$ ). The growth responses varied depending on the bacterial strain, chemicals, and dose tested. At 0.25 and 0.1 mg/disk, quinoline-4-carboxaldehyde strongly inhibited the growth of Clostridium perfringens and weakly inhibited the growth of Escherichia coli without any adverse effects on the growth of three lactic acid bacteria. Furthermore, at 0.05 and 0.025 mg/disk, this isolate showed moderate activity against C. perfringens. In comparison, chloramphenicol at as low as 0.01 mg/disk significantly inhibited the growth of all bacteria tested, and cinnamaldehyde at 0.25 mg/disk did not inhibit Bifidobacterium bifidum, B. longum, E. coli, and Lactobacillus acidophilus, with the exception of C. perfringens. The structure-activity relationship revealed that quinoline-3-carboxaldehyde had strong growth inhibition against C. perfringens, but quinoline, quinoline-3-carboxylic acid, and quinoline-4-carboxylic acid did not inhibit the growth of B. bifidum, B. longum, C. perfringens, E. coli, and L. acidophilus. These results indicate that the carboxyl aldehyde functional group of quinolines seems to be required for growth-inhibiting activity against C. perfringens, thus indicating at least one of the pharmacological actions of R. chalepensis leaf.


  • 주제어

    Clostridium perfringens .   inhibition .   intestinal bacteria .   quinoline-4-carboxaldehyde .   Ruta chalepensis.  

  • 참고문헌 (28)

    1. Granum, P. E. 1990. Clostridium perfringens toxins involved in food poisoning. Int. J. Food Microbiol. 10: 101-112 
    2. Nowak, J. and K. H. Steinkraus. 1988. Effect of tempeh fermentation of peas on their potential flatulence productivity as measured by gas production and growth of Clostridium perfringens. Nutr. Rep. Int. 38: 1163-1171 
    3. Phuapradit, P., W. Varavithya, K. Vathanophas, R. Sangchai, A. Podhipak, U. Suthutvoravut, S. Nopchinda, V. Chantraruksa, and F. Haschke. 1999. J. Med. Assoc. Thailand 1: 43-48 
    4. Salminen, S., E. Isolauri, and E. Salminen. 1984. Clinical uses of probiotics for stabilizing the gut mucosal barrier: Successful strains and future challenges. Antonie van Leeuwenhoek 70: 347-358 
    5. Skar, V., A. G. Skar, and J. H. Sromme. 1988. Beta-glucuronidase activity related to bacterial growth in common bile duct bile in gallstone patients. Scand. J. Gastroenterol. 23: 83-90 
    6. Talarico, T. L. and W. J. Dobrogosz. 1989. Chemical characterization of an antimicrobial substance produced by Lactobacillus reuteri. Antimicrob. Agents Chemother. 33: 674-679 
    7. Tissier, H. 1906. Traitement des infections intestinales par la methodle de la flore bactertienne de intestin. Crit. Rev. Soc. Biol. 60: 359-361 
    8. Paulini, H., R. Popp, O. Schimmer, O. Ratka, and E. Roder. 1991. Isogravacridonchlorine: A potent and direct acting frameshift mutagen from the roots of Ruta graveolens. Planta Medica 57: 59-61 
    9. Myhara, R. M., K. Nilsson, E. J. Bowmer, and P. K. Cruickshank. 1988. Gas production from melibiose, raffinose and white bean extracts by bacteria of human fecal origin. Can. Inst. Food Sci. Technol. J. 21: 245-251 
    10. Hwang, Y. H. and H. S. Lee. 2002. Antibacterial activity of Pinus densiflora leaf-derived components toward human intestinal bacteria. J. Microbiol. Biotechnol. 12: 610-616 
    11. Kim, J. D., H. Y. An, J. H. Yoon, Y. H. Park, F. Kawai, C. M. Jung, and K. H. Kang. 2002. Identification of Clostridium perfringens AB&J and its uptake of bromophenol blue. J. Microbiol. Biotechnol. 44: 544-552 
    12. Nieschulz, O. 1966. Pharmakol. Abstract. Chem. Fabrik Promonta G.M.B.H., Hamburg, Germany, Hanc, Oldrich, Ed. Sci. Pharm. Proc. 25th, Butterworths: London, England, 559-564. CAN 70: 18805 
    13. Szendrei, K., E. Minker, M. Koltai, J. Reisch, J. Novak, and G. Buzas. 1968. Quaternary alkaloids from Ruta graveolens L. Pharmazie 23: 519-520 
    14. Ulubelen, A. and H. Guner. 1988. Isolation of dehydromoskachan C from Ruta chalepensis var. Latifolia. J. Nat. Prod. 51: 1012-1013 
    15. Lee, H. S. and Y. J. Ahn. 1998. Growth-inhibiting effects of Cinnamomum cassia bark-derived materials on human intestinal bacteria. J. Agric. Food Chem. 46: 8-12 
    16. Malinckrodt Chemicals, 2002. Material Safety Data Sheet, Toxicological information MSDS N0090, Mallinckrodt Baker. Inc 
    17. Savage, D. C. 1977. Microbial ecology of the gastrointestinal tract. Annu. Rev. Microbiol. 31: 107-133 
    18. Mallett, A. K., I. R. Rowland, C. A. Bearne, J. C. Flynn, B. J. Fehilly, S. Udeen, and M. J. G. Farthing. 1988. Effect of dietary supplements of apple pectin, wheat bran or fat on the enzyme activity of the human faecal flora. Microbiol. Ecol. Health Dis. 1: 23-32 
    19. Benno, Y. 1990. Effect of diets on human fecal microflora. Bifidus 4: 1-8 
    20. Guandalini, S., L. Pensabene, M. A. Zikri, J. A. Dias, L. G. Casail, H. Hoekstra, S. Kolacek, K. Massar, D. MiceticTurk, A. Papadopoulou, J. S. Sousa, B. Sandhu, H. Szajewska, and Z. Weizman. 2000. Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: A multicenter European trial. J. Pediatr. Gastroenterol. Nutr. 30: 54-60 
    21. Lee, H. S. 2003. Inhibitory effects of quinizarin isolated from Cassia tora seeds against human intestinal bacteria and aflatoxin $B_1$ biotransformation. J. Microbiol. Biotechnol. 13: 529-536 
    22. Ghazanfar, S. A. 1994. Handbook of Arabian Medicinal Plants, pp. 190. CRC Press: Boca Raton, FL 
    23. Mitsuoka, T. 1990. Bifidobacteria and their role in human health. J. Indust. Microbiol. 6: 263-268 
    24. Oberhelman, R. A., R. H. Gilman, P. Sheen, D. N. Taylor, R. E. Black, L. Cabrera, A. G. Lescano, R. Meza, and G. Madico. 1999. A placebo-controlled trial of Lactobacillus GG to prevent diarrhea in undernourished Peruvian children. J. Pediatr. 134: 15-20 
    25. Kim, M. J., S. H. Lee, J. H. Cho, M. K. Kim, and H. S. Lee. 2003. Growth-responses of seven intestinal bacteria against Phellodendron amurense root-derived materials. J. Microbiol. Biotechnol. 13: 522-528 
    26. Ulubelen, A., B. Terem, E. Tuzlaci, K. F. Cheng, and Y. C. Kong. 1986. Alkaloids and coumarins from Ruta chalepensis. Phytochemistry 25: 2692-2693 
    27. Black, F., K. Einarsson, A. Lidbeak, K. Orrhage, and C. E. Nord. 1991. Effect of lactic acid producing bacteria on the human intestinal microflora during ampicillin treatment. Scand. J. Infect. Dis. 23: 247-254 
    28. McDonel, J. L. 1980. Clostridium perfringens toxins (Type A, B, C, D). Pharmac. Ther. 10: 617-655 
  • 이 논문을 인용한 문헌 (6)

    1. 2006. "" Food science and biotechnology, 15(5): 817~819     
    2. 2006. "" Journal of microbiology and biotechnology, 16(4): 639~642     
    3. 2009. "" Journal of the Korean Society for Applied Biological Chemistry, 52(2): 202~205     
    4. 2009. "" Journal of the Korean Society for Applied Biological Chemistry, 52(4): 331~335     
    5. 2011. "" Journal of the Korean Society for Applied Biological Chemistry, 54(1): 118~123     
    6. 2015. "" Journal of applied biological chemistry, 58(1): 5~8     

 저자의 다른 논문

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기