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Journal of microbiology and biotechnology v.15 no.4, 2005년, pp.891 - 894   피인용횟수: 6

Terrein, a Melanin Biosynthesis Inhibitor, from Penicillium sp. 20135

KIM WON-GON    (Korea Research Institute of Bioscience and Biotechnology   ); RYOO IN-JA    (Korea Research Institute of Bioscience and Biotechnology   ); PARK SEO-HYOUNG    (Department of Dermatology, Seoul National University College of Medicine   ); KIM DONG-SEOK    (Department of Dermatology, Seoul National University College of Medicine   ); LEE SANGKU    (Korea Research Institute of Bioscience and Biotechnology   ); PARK KYOUNG-CHAN    (Department of Dermatology, Seoul National University College of Medicine   ); YOO ICK-DONG    (Korea Research Institute of Bioscience and Biotechnology  );
  • 초록

    In the course of screening a melanin biosynthesis inhibitor, terrein, 4,5-dihydroxy-3-propenyl-2-cyclopenten-l-one, was isolated from Penicillium sp. Terrein was found to have a strong inhibitory activity on melanin formation in B 16 melanoma and melanocyte Mel-Ab cells.


  • 주제어

    Terrein .   melanin .   Penicillium.  

  • 참고문헌 (21)

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    4. Kim, J.-P., B.-K. Kim, B.-S. Yun, J.-J. Ryoo, I.-K. Lee, W.-G Kim, S. Lee, Y.-R. Pyun, and I.-D. Yoo. 2003. Melanocins A, Band C, new melanin synthesis inhibitors produced by Eupenicillium shearii. I. Physico-chemical properties and structure elucidation. J. Antibiot. 56: 1000-1003 
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    8. Kolb, H. C., H. Hoffinann, and R. Martin. 1990. A total synthesis of racemic and optically active terrein (trans-4,5dihydroxy-3-[(${\beta}$)-1-propenyl]-2-cyclopenten-I-one). Tetrahedron: Asymmetry 1: 237-250 
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    13. Lim, H. Y., M. K. Kim, Y. H. Cho, J. M. Kim, Y. H. Lim, and C. H. Lee. 2004. Inhibition of cell cycle progression and induction of apoptosis in HeLa cells by HY558-1, a novel CDK inhibitor isolated from Penicilliulll. minioluteum F558. J. Microbiol. Biotechnol. 14: 978-984 
    14. Hyeon, J. D., K. D. Park, S. H. Kim, K. R. Kim, S. W. Choi, J. T. Kim, K. H. Choi, and J. H. Kim. 2004. Identification of Streptomyces sp. producing antibiotics against phytopathogenic fungi, and its structure. J. Microbiol. Biotechnol. 14: 212-215 
    15. Mitscher, L. A., G. W. Clark III, and G. H. Bokelman. 1978. Method for the preparation of prostaglandin intermediates from a mold metabolite. U. S. Patent 4103091 (Jul. 25, 1978) 
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    18. Rhee, K. H. 2003. Purification and identification of an antifungal agent from Streptomyces sp. KH-614 antagonistic to rice blast fungus, Pyricularia oryzae. J. Microbiol. Biotechnol. 13: 984-988 
    19. Vi, Y. S., S. H. Kim, M. W. Kim, G J. Choi, K. Y. Cho, J. K. Song, and Y. H. Lim. 2004. Antifungal activity of Streptomyces sp. against Puccinia recondite causing wheat leaf rust. J. Microbiol. Biotechnol. 14: 422-425 
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