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생명과학회지 = Journal of life science v.15 no.4 = no.71, 2005년, pp.619 - 625   피인용횟수: 4

Streptozotocin-유발 당뇨쥐에 대한 함초 요구르트의 생리학적 효능
Physiological Effect of Hamcho Yogurt on Streptozotocin-Induced Diabetic Rats

차재영    (동아대학교 응용생명공학부   ); 전병삼    (㈜바이오허브 부설연구소   ); 김범규    (㈜바이오허브 부설연구소   ); 강호영    (부산대학교 생명과학부   ); 조영수    (동아대학교 응용생명공학부  );
  • 초록

    함초 추출물 분말을 첨가하여 유산 발효시킨 함초 요구르트를 streptozotocin-유발 당뇨쥐에 투여하여 항당뇨효과 및 콜레스테롤 저하 효과를 규명하기 위하여 3주간 실험하였다. 당뇨 대조군에 비해 함초 요구르트 투여군에서 혈당치 농도 및 식이 섭취량이 현저히 감소하였다. 경구당부하 실험에서도 당뇨 대조군에 비해 함초 요구르트 투여군에서 현저한 혈당상승 억제작용을 나타내었다. 당뇨쥐에 함초 요구르트와 일반 요구르트 섭취에 의해 혈중 총 콜레스테롤 농도 감소와 더불어 동맥경화지수도 감소하였다. 따라서, 함초 요구르트에 의한 혈당치 및 콜레스테롤 농도 감소효과는 고혈당증 및 고 콜레스테롤 혈중에도 유익한 작용을 할 수 있는 기능성식품 개발 가능성이 있음을 시사하였다.


    The present study was undertaken to investigate the hypoglycemic effect of Hamcho yogurt fermented by lactic acid bacteria containing Hamcho (Salicornia herbacea) extract powder in streptozotocin(STZ)-induced diabetic rats for 3 week period. The Hamcho yogurt given to the STZ-diabetic rats had significant effect in lowering the serum glucose concentrations and food intakes compared to the STZ-diabetic rats. The Hamcho yogurt administration increased the tolerance to oral glucose loading in the STZ-diabetic rats. The Hamcho yogurt and yogurt given to the STZ-diabetic rats were significantly decreased the serum total cholesterol concentration and the atherogenic index. Based on the beneficial effect against the blood glucose and cholesterol levels, we suggest the Hamcho yogurt can be used as functional food for the hypoglycemic and hypocholesterolemic effects.


  • 주제어

    Hamcho yogurt .   hypoglycemic effect .   streptozotocin .   diabetes.  

  • 참고문헌 (36)

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  • 이 논문을 인용한 문헌 (4)

    1. Kim, Kyung-Ran ; Choi, Jeong-Hwa ; Woo, Mi-Hee ; Kim, Young-Hee ; Choi, Sang-Won 2008. "Effects of Enzymatic Hydrolysates from Hamcho (Salicornia herbacea L.) on Blood Glucose and Serum Lipid Composition in Streptozotocin-Induced Diabetic Rats" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 37(2): 170~176     
    2. Kang, Smee ; Hong, Jungil 2016. "Antioxidant activities, production of reactive oxygen species, and cytotoxic properties of fractions from aerial parts of glasswort (Salicornia herbacea L.)" 한국식품과학회지 = Korean journal of food science and technology, 48(6): 574~581     
    3. Lee, Jung-Nam ; Kim, Mi-Sun ; Kim, Deuk Hoi ; Sohn, Ho-Yong 2016. "Anti-oxidation and Anti-thrombosis Activities of Different Parts of Salicornia herbacea L" Microbiology and biotechnology letters = 한국미생물·생명공학회지, 44(3): 311~316     
    4. Kim, Mi-Sun ; Lee, Jung-Nam ; Seong, Ha-Jung ; Kim, Deuk Hoi ; Sohn, Ho-Yong 2016. "Changes in the in vitro Antioxidant and Antithrombosis Activities of Salicornia europaea According to Harvest Time" 생명과학회지 = Journal of life science, 26(9): 1033~1040     

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