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Anxiolytic-like Effects of Polygala tenuifolia Willdenow Using the Elevated Plus Maze and Hole-board Apparatus in Mice

Jung, Ji-Wook    (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University   ); Yoon, Byung-Hoon    (Department of Oriental Pharmaceutical Science, College of Pharmacy   ); Kim, Sun-Yeou    (Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University   ); Cheong, Jae-Hoon    (Department of Pharmacy, Sahmyook University   ); Ryu, Jong-Hoon    (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University  );
  • 초록

    The purpose of this study was to characterize the putative anxiolytic-like effects of the aqueous extract of the root of Polygala tenuifolia ( AEPT) using an elevated plus maze (EPM) and hole-board apparatus in mice. The AFPT was orally administered at 50, 100, 200 or 400 mg/kg to ICR mice, 1 h before the behavioral evaluation in the EPM respectively. Control mice were treated with an equal volume of saline, and positive control mice with buspirone (2 mg/kg). Single treatments of the AEPT significantly increased the percentage of time spent and arm entries into the open arms of the EPM vedrsus saline controls (P $HT_{1A}$ receptor antagonist not by flumazenil, a $GABA_{A}$ antagonist. These results indicate that P. tenuifolia is an effective anxiolytic agent, andsuggest that the anxiolytic-like effects of P. tenuifolia is mediated via the serotonergic nervous system.


  • 주제어

    Anxiety .   Polygala tenuifolia .   elevated plus-maze .   WAY 100635 .   flumazenil.  

  • 참고문헌 (19)

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