본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Food science and biotechnology v.14 no.2 = no.62, 2005년, pp.259 - 262   피인용횟수: 4

Isolation and Characterization of a Water-Soluble Polysaccharide from the Mycelia of Solid Cultured Agaricus blazei Murill

Chung, Ha-Yull    (Department of Food Science & Biotechnology, and Food & Biotechnology Research Center, Hankyong National University   ); Cho, Young-Jun    (Department of Food Science & Biotechnology, and Food & Biotechnology Research Center, Hankyong National University   ); Kim, Tae-Wook    (Department of Food Science & Biotechnology, and Food & Biotechnology Research Center, Hankyong National University  );
  • 초록

    A fraction (CMEx-AH- ${\beta}$ ) of water-soluble polysaccharides, showing selective antitumor activities, was isolated from the mycelia of solid cultured Agaricus blazei Murill by hot-water extraction, ethanol precipitation, and series of chromatography. Chemical characteristics of CMEx-AH- ${\beta}$ , were as follows: carbohydrate content, 48%; monosaccharide composition, Man:Glu:Gal (2:93:5); molecular weight, $2{\times}10^5$ ; uronic acid content, 6.2%. Fundamental structure of CMEx-AH- ${\beta}$ , was deduced as ${\beta}-(1\;{\rightarrow}\;6)$ -D-glucan with ${\beta}-(1\;{\rightarrow}\;3)$ -D-glucosidic side chains based on results of methylation and $^{13}C$ NMR spectroscopic analyses.


  • 주제어

    Agaricus blazei Murill .   chemical characteristics .   fundamental structure.  

  • 참고문헌 (19)

    1. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides (review) , Wasser, S.P. , Appl. Microbiol. Biotechnol. / v.60,pp.258-274,
    2. Agaricus blazei Murill: medicinal and dietary effects , Kawariharatake, Mizuno, T. , Food Rev. Intern. / v.11,pp.167-172,
    3. Therapeutic effects of substances occurring in higher basidomecetes mushroom , Wasser, S.P.;Weiss, A.L. , A Modern Perspective. Crit. Rev. Immunol. / v.19,pp.65-69,
    4. Antimutagenic and bacterial substances in the fruit body of basidomycetes, Agaricus blazei , Osaki, Y.;Kato, T.;Tamamoto, T.;Okubo, J.;Miyazaki, T. , Yakugaku Zasshi / v.114,pp.342-350,
    5. antitumor polysaccharide from the mycelium of Iiquid-cultured Agaricus blazei Murill , Mizuno, M.;Minato, K.;Ito, H.;Kawade, M.;Terai, H.;Tsuchida, H. , Biochem. Mol. BioI. Int. / v.47,pp.707-714,
    6. Antimetastatic effects of PSK, a protein-bound polysaccharide obtained from Badidiomycetes: an overview (review) , Kobayashi, H.;Matsunaga, K.;Oguchi, Y. , Cancer Epidemiol. Biomarkers Prev. / v.4,pp.275-281,
    7. Culturing process of mushroom mycelia using edible by-products , Chung, H.Y. , / v.,pp.,
    8. The selective antitumor activity of water-soluble extracts of the fruiting bodies and the cultivated mycelia of Agaricus blazei Murill , Kim, J.E.;Lee, W.S.;Chung, H.Y.;Jang, S.J.;Kim, J.S.;Lee, J.B.;Song, C.S.;Park, S.Y. , Food Sci. Biotechnol. / v.13,pp.347-352,
    9. Colorimetric method for determination of sugars and related substances , Dubois, M.;Gilles, K.A.;Hamilton, J.K.;Rebers, P.A.;Smith, F. , Anal. Chem. / v.28,pp.350-356,
    10. Protein measurement with the folin phenol reagent , Lowry, O.H.;Rosebrough, N.J.;Farr, A.L.;Randall, R.J. , J. BioI. Chem. / v.193,pp.265-275,
    11. A photometric adaptation of the somogyi method for the determination of glucose , Nelson, N.;Somogyi, M. , J. BioI. Chem. / v.153,pp.375-380,
    12. A colorimetric method for the quantitation of glucuronic acids and a specific assay for galacturonic acid , Taylor, K.A.;Buchanan-Smith, J.G. , Anal. Biochem. / v.201,pp.190-196,
    13. Permethylation of polysaccharides by a modified Hakomori method , Narui, T.;Takahashi, K.;Kobayashi, M.;Shibata, S. , Carbohyd. Res. / v.103,pp.293-295,
    14. Methods in Carbohydrate Chemistry, Vol. 5 , Goldstein, I.J.;Hay, G.W.;Lewis, B.A.;Smith, F.;Whistler, R.L.(ed.) , / v.,pp.347-361,
    15. Structua] characterization of a water-soluble ${\beta}$-D-glucan from fruiting bodies of Agaricus blazei Murill , Dong, Q.;Yao, J.;Yang, X.T.;Fang, J.N. , Carbohyd. Res. / v.337,pp.1417-1421,
    16. Formolysis of a potent antitumor ($1{\to}6$)-${\beta}$-glucan-protein complex from Agaricus blazei fruiting bodies and antitumor activity of the resulting products , Kawagishi, H.;Kanao, T.;Inagaki, R.;Mizuno, T. , Carbohyd. Polymers / v.12,pp.393-403,
    17. Fractionation and antitumor activity of the water-insoiuble residue of Agaricus blazei fruiting bodies , Kawagishi, H.;Inagaki, R.;Kanao, T.;Mizuno, T. , Carbohyd. Res. / v.186,pp.267-273,
    18. antitumor polysaccharide from P. ostreatus (FR.) QUEL.: isolation and structure of a ${\beta}$-glucan , Yoshioka, Y.;Tabeta, R.;Saito, H.;Uehara, N.;Fukuoka, F. , Carbohyd. Res. / v.140,pp.93-100,
    19. Extraction and purification of bioactive materials from Agaricus blazei fruiting bodies , Choi, J.W.;Ryu, D.R.;Kim, Y.K.;Hong, E.G.;Kwon, M.S.;Han, J.S. , Korean J. Biotechnol. Bioeng. / v.15,pp.293-298,
  • 이 논문을 인용한 문헌 (4)

    1. 2006. "" Food science and biotechnology, 15(6): 889~895     
    2. 2007. "" Food science and biotechnology, 16(4): 600~604     
    3. 2009. "" Food science and biotechnology, 18(3): 667~671     
    4. 2009. "" Food science and biotechnology, 18(3): 667~671     

 저자의 다른 논문

  • Chung, Ha-Yull (22)

    1. 1999 "쑥의 에탄올 추출물에 함유된 Flavonoid들의 분리 및 동정과 이들의 항산화 효과" 한국식품과학회지 = Korean journal of food science and technology 31 (3): 815~822    
    2. 2000 "13종 허브추출물의 수퍼옥사이드 소거능과 세포독성 및 면역증강 효과의 in vitro계 검색" 한국식품과학회지 = Korean journal of food science and technology 32 (3): 699~705    
    3. 2000 "3가지 약용 허브 추출물에 함유된 유기산 검색 및 조성 비교" 한국식품과학회지 = Korean journal of food science and technology 32 (5): 997~1001    
    4. 2002 "포도종실 에탄올 추출물의 항산화 활성" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition 31 (5): 893~898    
    5. 2002 "포도종실 에탄올 추출물의 순차 용매 분획에 따른 항산화 활성" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition 31 (6): 1092~1096    
    6. 2003 "포도종실 에탄올 추출물의 항균 활성" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition 32 (1): 109~114    
    7. 2005 "포도종실 에탄올 추출물에 함유된 (+)-카테킨, (-)-에피카테킨의 모세관 전기영동법에 의한 분석" 한국식품과학회지 = Korean journal of food science and technology 37 (4): 513~518    
    8. 2005 "Isolation and Characterization of a Water-Soluble Polysaccharide from the Mycelia of Solid Cultured Phellinus linteus" Food science and biotechnology 14 (6): 783~787    
    9. 2008 "흑참깨분으로 착유한 참기름의 산화안정성" 한국식품과학회지 = Korean journal of food science and technology 40 (2): 141~145    
    10. 2008 "마늘과 대두배아 발효물로 구성된 복합 식품소재가 고지방 식이를 섭취한 흰쥐의 혈중 지질 성분에 미치는 영향" 한국식품과학회지 = Korean journal of food science and technology 40 (2): 215~219    
  • Kim, Tae-Wook (1)

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • NDSL :
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기