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Food science and biotechnology v.14 no.2 = no.62, 2005년, pp.290 - 296   피인용횟수: 10

Effects of Chrysanthemum boreale M. Water Extract on Serum Liver Enzyme Activities and Kupffer Cells of Carbon Tetrachloride-Induced Rats

Jeon, Jeong-Ryae    (Department of Food and Nutrition, Yeungnam University   ); Park, Jyung-Rewng    (Department of Food and Nutrition, Yeungnam University  );
  • 초록

    Effects of water extract obtained from Chrysanthemum boreale M. (CE) on serum enzyme activities and Kupffer cells of carbon tetrachloride ( $CCl_4$ )-induced rats were investigated. Thirty-two healthy male Sprague-Dawley rats were divided into normal (N), $CCl_4$ -induced (T), CE-supplemented (C), and $CCl_4$ -induced and CE-supplemented (TC) groups. $CCl_4$ injection significantly increased aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and alkaline phosphatase activities in serum. Significant increases in total cholesterol and triglyceride concentrations were also observed in $CCl_4$ -induced rats. Oral administration of CE at 300 mg/kg body weight significantly decreased serum enzyme levels and suppressed $CCl_4$ hepatotoxicity-induced lipid profile changes. Histological findings showed fatty change, fibrosis and increased number of Kupffer cells in T group. Electron microscopic examination showed increased lysosome content and dilation of rough endoplasmic reticulum within Kupffer cells in T group, whereas CE supplement attenuated liver injury in $CCl_4$ -induced liver. These results indicated CE could significantly alleviate CC4-induced hepatotoxicity injury.


  • 주제어

    Chrysanthemum boreale .   carbon tetrachloride .   Kupffer cell .   hepatotoxicity .   histological examination.  

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