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Food science and biotechnology v.14 no.3 = no.63, 2005년, pp.405 - 409   피인용횟수: 3

Effects of Intraperitoneal Administration of Lactococcus lactis ssp. lactis Cellular Fraction on Immune Response

Kim, Ji-Yeon    (Department of Food Standard Evaluation, Korea Food & Drug Administration   ); Lee, Seong-Kyu    (Department of Applied Biological Chemistry, The University of Tokyo   ); Jeong, Do-Won    (School of Agricultural Biotechnology, and Center of Agricultural Biomaterials, Seoul National University   ); Hachimura, Satoshi    (Department of Applied Biological Chemistry, The University of Tokyo   ); Kaminogawa, Shuichi    (Department of Food Science and Technology, College of Bioresource Science, Nihon University   ); Lee, Hyong-Joo    (School of Agricultural Biotechnology, and Center of Agricultural Biomaterials, Seoul National University  );
  • 초록

    Cellular components of Lactococcus lactis ssp. lactis (heat-killed whole cells, cytoplasm, and cell walls) were tested for their in vivo immunopotentiating activities. Peritoneal macrophages from mice injected intraperitoneally with cell-wall fractions exhibited significantly greater phagocytic activity than groups injected with whole cells or cytoplasm fraction. Cytotoxicity of natural-killer cells was highest in cytoplasm fractions. Production of cytokines (IFN- ${\gamma}$ , IL-2, IL-6, and IL-12) in spleen cells was significantly higher when cellular components were injected intraperitoneally, and tended to be higher in whole-cell and cytoplasm groups than in cell-wall group. These results demonstrate lactic acid bacteria whole cells and their cytoplasm and cell-wall tractions have immunopotentiating activities.


  • 주제어

    Cytokine .   Lactococcus lactis ssp.   lactis .   NK cell activity .   Phagocytic activity .   Immunopotentiating activity.  

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  • 이 논문을 인용한 문헌 (3)

    1. 2007. "" Journal of microbiology and biotechnology, 17(8): 1227~1235     
    2. 2008. "" Food science and biotechnology, 17(6): 1221~1227     
    3. 2009. "" Food science and biotechnology, 18(2): 396~401     

 저자의 다른 논문

  • Lee, Seong-Kyu (2)

    1. 2003 "In Vitro Immunopotentiating Activity of Cellular Components of Lactococcus lactis ssp. lactis" Journal of microbiology and biotechnology 13 (2): 202~206    
    2. 2006 "In Vivo Immunopotentiating Effects of Cellular Components from Lactococcus lactis ssp. lactis" Journal of microbiology and biotechnology 16 (5): 786~790    
  • 정도원 (8)

  • Lee, Hyong-Joo (81)

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