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Asian-Australasian journal of animal sciences v.18 no.1, 2005년, pp.3 - 7   피인용횟수: 3

Identification of Novel SNPs in Bovine Insulin-like Growth Factor Binding Protein-3 (IGFBP3) Gene

Kim, J.Y.    (Department of Genetic Epidemiology, SNP Genetics, Inc.   ); Yoon, D.H.    (National Livestock Research Institute, RDA   ); Park, B.L.    (Department of Genetic Epidemiology, SNP Genetics, Inc.   ); Kim, L.H.    (Department of Genetic Epidemiology, SNP Genetics, Inc.   ); Na, K.J.    (National Livestock Research Institute, RDA   ); Choi, J.G.    (National Livestock Research Institute, RDA   ); Cho, C.Y.    (National Livestock Research Institute, RDA   ); Lee, H.K.    (Department of Biotechnology, Hankyong National University   ); Chung, E.R.    (Department of Biotechnology, Sangi University   ); Sang, B.C.    (Department of Dairy Science, Graduate School, Chungnam National University   ); Cheong, I.J.    (National Livestock Research Institute, RDA   ); Oh, S.J.    (National Livestock Research Institute, RDA   ); Shin, Hyoung Doo    (Department of Genetic Epidemiology, SNP Genetics, Inc.  );
  • 초록

    The insulin-like growth factors (IGFs), their receptors, and their binding proteins play key roles in regulating cell proliferation and apoptosis. Insulin-like growth factor binding protein-3 (IGFBP3, OMIM #146732) is one of the proteins that bind to the IGFs. IGFBP3 is a modulator of IGF bioactivity, and direct growth inhibitor in the extravascular tissue compartment. We identified twenty-two novel single nucleotide polymorphisms (SNPs) in IGFBP3 gene in Korean cattle (Hanwoo, Bos taurus coreanae) by direct sequencing of full gene including -1,500 bp promoter region. Among the identified SNPs, five common SNPs were screened in 650 Korean cattle; one SNP in promoter (IGFBP3 G-854C), one in 5'UTR region (IGFBP3 G-100A), two in intron 1 (IGFBP3 G+421T, IGFBP3 T+1636A), and one in intron 2 (IGFBP3 C+3863A). The frequencies of each SNP were 0.357 (IGFBP3 G-854C), 0.472 (IGFBP3 G-100A), 0.418 (IGFBP3 G+421T), 0.363 (IGFBP3 T+1636A) and 0.226 (IGFBP3 C+3863A), respectively. Haplotypes and their frequencies were estimated by EM algorithm. Six haplotypes were constructed with five SNPs and linkage disequilibrium coefficients (|D'|) between SNP pairs were also calculated. The information on SNPs and haplotypes in IGFBP3 gene could be useful for genetic studies of this gene.


  • 주제어

    Insulin-like Growth Factor Binding Protein-3 (IGFBP3) .   Single Nucleotide Polymorphism (SNP) .   Haplotype .   Linkage Disequilibrium (LD).  

  • 참고문헌 (19)

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  • 이 논문을 인용한 문헌 (3)

    1. 2007. "" Asian-Australasian journal of animal sciences, 20(9): 1334~1341     
    2. 2007. "" Asian-Australasian journal of animal sciences, 20(9): 1342~1348     
    3. 2008. "" Asian-Australasian journal of animal sciences, 21(3): 309~313     

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